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Transitional cell cancer of the renal pelvis and ureter


Table of Contents

OVERVIEW OF PDQ
What is PDQ?
How to use PDQ
DESCRIPTION
What is transitional cell cancer of the renal pelvis and ureter?
STAGE EXPLANATION
Stages of transitional cell cancer of the renal pelvis and ureter
Localized
Regional
Metastatic
Recurrent
TREATMENT OPTION OVERVIEW
How transitional cell cancer of the renal pelvis and ureter is treated
Treatment by stage
LOCALIZED TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER
REGIONAL TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER
METASTATIC TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER
RECURRENT TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER
TO LEARN MORE

OVERVIEW OF PDQ


What is PDQ?

PDQ is a computer system that gives up-to-date information on cancer and its prevention, detection, treatment, and supportive care. It is a service of the National Cancer Institute (NCI) for people with cancer and their families and for doctors, nurses, and other health care professionals.

To ensure that it remains current, the information in PDQ is reviewed and updated each month by experts in the fields of cancer treatment, prevention, screening, and supportive care. PDQ also provides information about research on new treatments (clinical trials), doctors who treat cancer, and hospitals with cancer programs. The treatment information in this summary is based on information in the PDQ summary for health professionals on this cancer.


How to use PDQ

PDQ can be used to learn more about current treatment of different kinds of cancer. You may find it helpful to discuss this information with your doctor, who knows you and has the facts about your disease. PDQ can also provide the names of additional health care professionals who specialize in treating patients with cancer.

Before you start treatment, you also may want to think about taking part in a clinical trial. PDQ can be used to learn more about these trials. A clinical trial is a research study that attempts to improve current treatments or finds information on new treatments for patients with cancer. Clinical trials are based on past studies and information discovered in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help patients with cancer. Information is collected about new treatments, their risks, and how well they do or do not work. When clinical trials show that a new treatment is better than the treatment currently used as "standard" treatment, the new treatment may become the standard treatment. Listings of current clinical trials are available on PDQ. Many cancer doctors who take part in clinical trials are listed in PDQ.

To learn more about cancer and how it is treated, or to learn more about clinical trials for your kind of cancer, call the National Cancer Institute's Cancer Information Service. The number is 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615. The call is free and a trained information specialist will be available to answer cancer-related questions.

PDQ is updated whenever there is new information. Check with the Cancer Information Service to be sure that you have the most up-to-date information.


DESCRIPTION


What is transitional cell cancer of the renal pelvis and ureter?

Transitional cell cancer (TCC) of the renal pelvis and ureter is a disease in which cancer (malignant) cells are found in the tissues in the kidneys that collect urine (the renal pelvis) and/or in the tube that connects the kidney to the bladder (ureter).

The kidneys are a "matched" pair of organs found on either side of your backbone. The kidneys of an adult are about 5 inches long and 3 inches wide and are shaped like a kidney bean. Inside each kidney are tiny tubules that clean your blood, taking out waste products and making urine. The urine made by the kidneys passes through the ureter into the bladder where it is held until it is passed from your body. The renal pelvis is the part of the kidney that collects urine and drains it to the ureters. The cells that line the renal pelvis and ureters are called transitional cells, and it is these cells that are affected in TCC. If you have a more common type of kidney cancer called renal cell cancer, see the patient information statement on renal cell cancer.

Like most cancers, TCC of the renal pelvis and ureter is best treated when it is found (diagnosed) early. In the early stages of TCC you may not have any symptoms. The symptoms of TCC and other types of kidney cancer are similar to other types of kidney disease. You should see your doctor if you have blood in your urine or pain in your back.

If you have symptoms, your doctor will usually feel your abdomen for lumps. A narrow lighted tube called a ureteroscope may be inserted through the bladder into the ureter so that your doctor can look inside the ureter and renal pelvis for signs of cancer. If cancer cells are found, your doctor may take out a small piece of the tissue to look at under the microscope. This is called a biopsy. Your doctor may also do a special x-ray called a CT scan or a scan that uses magnetic waves (MRI) to look for lumps.

Your chance of recovery (prognosis) and choice of treatment depend on the stage of your cancer (whether it is just in the tissue lining the inside of the ureter or renal pelvis or has spread to other places) and your general state of health.


STAGE EXPLANATION


Stages of transitional cell cancer of the renal pelvis and ureter

Once transitional cell cancer is found, more tests will be done to find out if cancer cells have spread to other parts of the body (staging). Your doctor needs to know the stage to plan treatment. The following stages are used for TCC of the renal pelvis and ureter:


Localized

The cancer is only in the area where it started and has not spread outside the kidney or ureter.


Regional

The cancer has spread to the tissue around the kidney or to lymph nodes in the pelvis. (Lymph nodes are bean-shaped structures that are found throughout the body. They produce infection-fighting cells.)


Metastatic

The cancer has spread to other parts of the body.


Recurrent

Recurrent disease means that the cancer has come back (recurred) after it has been treated. It may come back in the original area or in another part of the body.


TREATMENT OPTION OVERVIEW


How transitional cell cancer of the renal pelvis and ureter is treated

There are treatments for all patients with transitional cell cancer of the renal pelvis and ureter. The primary treatment is surgery (taking out the cancer in an operation). Radiation therapy (using high-dose x-rays to kill cancer cells), biological therapy (using your body's immune system to fight cancer), and chemotherapy (using drugs to kill cancer cells) are being tested in clinical trials.

Surgery is the most common treatment of transitional cell cancer of the renal pelvis and ureter. Your doctor may remove the tumor using one of the following operations:

The kidney, ureter, and top part of the bladder may be removed in an
operation called a nephroureterectomy.

Segmental resection removes only part of the ureter or kidney.

Electrosurgery uses an electric current to remove the cancer. The tumor and
the area around it are burned away and then removed with a sharp tool.

Laser therapy uses a narrow beam of intense light to remove cancer cells.

Electrosurgery and laser therapy are used only for cancers that are on the surface of the renal pelvis or ureter.

Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill, or it may be put into the body by a needle in the vein or muscle. Chemotherapy is called a systemic treatment because the drug enters the bloodstream, travels through the body, and can kill cancer cells throughout the body. Chemotherapy may also be put directly into the ureter or pelvis (intraureteral or intrapelvic chemotherapy).

Biological therapy tries to get your own body to fight cancer. It uses materials made by your own body or made in a laboratory to boost, direct, or restore your body's natural defenses against disease. Biological therapy is sometimes called biological response modifier (BRM) therapy or immunotherapy.

Radiation therapy uses high-energy x-rays to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external beam radiation therapy) or from putting materials that produce radiation (radioisotopes) through thin plastic tubes (internal radiation therapy) in the area where the cancer cells are found.


Treatment by stage

Your choice of treatment depends on how far the cancer has spread and your general health.

You may receive treatment that is considered standard based on its effectiveness in a number of patients in past studies, or you may choose to go into a clinical trial. Not all patients are cured with standard therapy and some standard treatments may have more side effects than are desired. For these reasons, clinical trials are designed to find better ways to treat cancer patients and are based on the most up-to-date information. Clinical trials are going on in most parts of the country for most stages of transitional cell cancer of the renal pelvis and ureter. If you want more information, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.


LOCALIZED TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER

Your treatment may be one of the following:

1. Surgery to remove the kidney, ureter, and the top part of the bladder (nephroureterectomy).

2. Surgery to remove part of the ureter or kidney (segmental resection).

3. A clinical trial of electrosurgery or laser therapy.

4. A clinical trial of intrapelvic or intraureteral chemotherapy or biological therapy.


REGIONAL TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER

Your treatment will probably be a clinical trial of radiation therapy and/or chemotherapy.


METASTATIC TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER

Your treatment will probably be a clinical trial of chemotherapy.


RECURRENT TRANSITIONAL CELL CANCER OF THE RENAL PELVIS AND URETER

Your treatment will probably be a clinical trial of new treatments.


TO LEARN MORE

TO LEARN MORE..... CALL 1-800-4-CANCER

To learn more about transitional cell cancer of the renal pelvis and ureter, call the National Cancer Institute's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615. By dialing this toll-free number, you can speak with someone who can answer your questions.

The Cancer Information Service can also send you booklets. The following booklets about kidney cancer may be helpful to you:

What You Need To Know About Kidney Cancer

The following general booklets on questions related to cancer may also be helpful:

What You Need To Know About Cancer
Taking Time: Support for People with Cancer and the People Who Care About
Them
What Are Clinical Trials All About?
Chemotherapy and You: A Guide to Self-Help During Treatment
Radiation Therapy and You: A Guide to Self-Help During Treatment
Eating Hints for Cancer Patients
Advanced Cancer: Living Each Day
When Cancer Recurs: Meeting the Challenge Again

There are many other places you can get information about cancer treatment and services to help you. You can check the social service office at your hospital for local and national agencies that help with your finances, getting to and from treatment, care at home, and dealing with your problems.

You can also write to the National Cancer Institute at this address:

National Cancer Institute
Office of Cancer Communications
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580

Date Last Modified: 09/1997


If you want to know more about cancer and how it is treated, or if you wish to know about clinical trials for your type of cancer, you can call the NCI's Cancer Information Service at 1-800-422-6237, toll free. A trained information specialist can talk with you and answer your questions.


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