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Patient Information

Patients should be informed that the major acute toxicity of intravenous NAVELBINE (vinorelbine tartrate) Injection is bone marrow toxicity, in particular granulocytopenia. Because granulocytopenia can result in an increased risk of infection, patients should immediately report any potential signs of infection, including fever and chills, to their physician. Women of childbearing potential should be advised to avoid becoming pregnant during treatment with NAVELBINE. See Tables 5 and 6 for patient information on possible side effects of single-agent NAVELBINE and NAVELBINE in combination with cisplatin. It is important to review this information with your patient, emphasizing management strategies.


Contents

TABLE 5.
Possible Side Effects of NAVELBINE (vinorelbine tartrate) Injection when used alone
  • Decreased white blood cell counts
  • Injection site reactions
  • Constipation
  • Mild or moderate nausea or vomiting
  • Severe nausea or vomiting
  • Hair thinning
  • Neurological problems (numbness, tingling, or weakness)
  • Fatigue/Tiredness
  • TABLE 6.
    Possible Side Effects of combination NAVELBINE (vinorelbine tartrate) Injection and cisplatin
  • Decreased white blood cell counts
  • Injection site reactions
  • Constipation
  • Mild or moderate nausea or vomiting
  • Severe nausea or vomiting
  • Reduced kidney function
  • Neurological problems (numbness, tingling, or weakness)
  • Hearing problems
  • Hair loss
  • Fatigue/Tiredness
  • [Back to Main Table of Contents]

    Table 5.

    Possible Side Effects of NAVELBINE (vinorelbine tartrate) Injection when used alone

    Decreased white blood cell counts

    When Might I Expect to Have This Side Effect?

    Within the first 2 to 3 weeks of treatment

    What Should I Do If I Have This Side Effect?

    Reduce risk of infection:

    When Should I Call My Doctor or Oncology Nurse?

    If you have:
    Back To Index

    Injection Site Reactions

    When Might I Expect to Have This Side Effect?

    During administration or for a few days thereafter

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    If you have:
    Back To Index

    Constipation

    When Might I Expect to Have This Side Effect?

    Increases after several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Whenever you:
    Back To Index

    Mild or moderate nausea or vomiting

    When Might I Expect to Have This Side Effect?

    Within 24 hours of treatment

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Whenever you:
    Back To Index

    Severe nausea or vomiting

    When Might I Expect to Have This Side Effect?

    This rarely occurs

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Whenever you:
    Back To Index

    Hair Thinning

    When Might I Expect to Have This Side Effect?

    After several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Back To Index

    Neurological problems
    (numbness, tingling, or weakness)

    When Might I Expect to Have This Side Effect?

    After several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    If you experience:
    Back To Index

    Fatigue/Tiredness

    When Might I Expect to Have This Side Effect?

    After several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Back To Index

    Table 6.

    Possible Side Effects of combination NAVELBINE (vinorelbine tartrate) Injection and cisplatin

    Decreased white blood cell counts

    When Might I Expect to Have This Side Effect?

    Within the first 2 to 3 weeks of treatment

    What Should I Do If I Have This Side Effect?

    Reduce risk of infection:

    When Should I Call My Doctor or Oncology Nurse?

    If you have:
    Back To Index

    Injection Site Reactions

    When Might I Expect to Have This Side Effect?

    During administration or for a few days thereafter

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    If you have:
    Back To Index

    Constipation

    When Might I Expect to Have This Side Effect?

    Increases after several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Whenever you:
    Back To Index

    Mild or moderate nausea or vomiting

    When Might I Expect to Have This Side Effect?

    1 to 4 hours after receiving cisplatin

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Whenever you:
    Back To Index

    Severe nausea or vomiting

    When Might I Expect to Have This Side Effect?

    1 to 4 hours after receiving cisplatin

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Whenever you:
    Back To Index

    Reduced kidney function

    When Might I Expect to Have This Side Effect?

    After several treatments

    What Should I Do If I Have This Side Effect?

    Watch for:

    When Should I Call My Doctor or Oncology Nurse?

    If you have
    Back To Index

    Neurological problems (numbness, tingling, or weakness)

    When Might I Expect to Have This Side Effect?

    After several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    If you have:
    Back To Index

    Hearing Problems

    When Might I Expect to Have This Side Effect?

    After several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    If you:
    Back To Index

    Hair Loss

    When Might I Expect to Have This Side Effect?

    After several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

    Back To Index

    Fatigue/Tiredness

    When Might I Expect to Have This Side Effect?

    After several treatments

    What Should I Do If I Have This Side Effect?

    When Should I Call My Doctor or Oncology Nurse?

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