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Drug Interactions

The incidence of some drug-associated toxicities, particularly granulocytopenia, is significantly higher in patients receiving combination therapy with NAVELBINE (vinorelbine tartrate) Injection and cisplatin as compared to patients treated with single-agent NAVELBINE (Grade 3-4=79% vs Grade 3-4=53%, respectively).[2]

As with other vinca alkaloids, acute pulmonary reactions have been reported infrequently with NAVELBINE used in conjunction with mitomycin. These pulmonary reactions, which are characterized by dyspnea and severe bronchospasm, may require treatment with supplemental oxygen, bronchodilators and/or corticosteroids.

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