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Key Points On AML

Table of Contents

Contributors to this publication

Etiology and Diagnosis
Age-specific myeloid leukemia incidence rates in the US
Etiology of acute myeloid leukemia
Development of the myeloid cell line
Classification
Morphologic features
Histochemical features
Peripheral blood features
Clinical diagnostic features
Diagnostically important AML markers
Work-up for patient with AML

Treatment
Prognostic factors
Definition of complete remission
Preparing the patient for definitive therapy
Definitive treatment strategies
Standard agents used to treat AML
Questions about optimal therapy
Development of present-day induction therapy
Baltimore Cancer Research Center Trial: Maintenance therapy
Factors correlating with response to therapy
Prognostic significance of MDR1 expression
AML in relapse
All-trans-retinoic acid in relapsed acute promyelocytic (M3) leukemia
Allogeneic bone marrow transplantation
Treatment statistics

Supportive Care
Infectious disease statistics in granulocytopenic patients
Methods to prevent infection
Treatment of neutropenic patients
Treatment of persistent fever
Antibiotic discontinuation in afebrile patients
Antibiotic discontinuation in febrile patients
Thrombocytopenia
Factors predisposing to thrombocytopenic bleeding
Platelet transfusion therapy
Assessing response to platelet transfusions

Summary and Future Directions
Summary
Future directions

Appendix
Consolidation
AML in relapse
Italian Cooperative Group GIMEMA Trial in AML Idarubicin/Ara-C vs Daunorubicin/Ara-C





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