Typical Immunophenotypes in AML[1,2]
CD |
Antibodies |
M1,M2 |
M3 |
M4,M5 |
M6 |
M7 |
Myeloid Lineage |
CD11b |
Mo1, Leu15 |
+/- |
+/- |
++ |
- |
- |
CD13 |
MY7, Leu-M7 |
++ |
++ |
++ |
++ |
+ |
CD14 |
MY4, Mo2, Leu-M3 |
+/- |
- |
++ |
++ |
- |
CD15 |
Leu-M1 |
++ |
++ |
++ |
++ |
- |
CD33 |
MY9, Leu-M9 |
++ |
++ |
++ |
++ |
+ |
T Lineage |
CD2 |
T11, Leu-5b |
+/- |
+/- |
+/- |
- |
- |
CD3 |
T3, Leu-4 |
- |
- |
- |
- |
- |
CD5 |
T1, Leu-1 |
- |
- |
- |
- |
- |
CD7 |
3A1, Leu-9 |
+- |
+/- |
+/- |
+/- |
+ |
B Lineage |
CD10 |
CALLA, J5 |
- |
- |
- |
- |
- |
CD19 |
B4, Leu-12 |
+/- |
- |
+/- |
- |
- |
CD20 |
B1, Leu-16 |
- |
- |
- |
- |
- |
Erythroid Lineage |
Glycophorin A |
D2.10 |
- |
- |
- |
++ |
- |
CD71 |
T9 |
- |
- |
- |
++ |
- |
Megakaryocyte Lineage |
CD41 |
gpIIb/IIIa |
- |
- |
- |
- |
++ |
CD42 |
gpIb |
- |
- |
- |
- |
++ |
CD61 |
gp/IIIa |
- |
- |
- |
- |
++ |
Stem Cell |
CD34 |
MY10, HPCA-1 |
+ |
- |
+/- |
+ |
+ |
CD38 |
Leu-17 |
+ |
+ |
+ |
+ |
+ |
Non-Lineage Dependent |
HLA-DR |
Ia, I3 |
++ |
- |
++ |
++ |
+/- |
|
|
*The following key refers to the majority, but not all cases. These are not absolutes.
|
++: Strong positivity: virtually all cases |
+/-: Occasional reactivity |
+: Positive, but not all cases |
-; Essentially negative |
References
- Bain BJ. "Immunological, cytogenetic and other markers." In: Knowles Z, ed. Leukemia Diangosis-
A Guide to the FAB Classification. Philadelphia, PA: JB Lippincott Co; 1990:61-88.
- Carey, JL, Hanson, CA. "Flow cytometric analysis of leukemia and lymphoma." In: Kerne DF, Hanson, CA, Hurtubise, PF,
eds. Flow Cytometry and Clinical Diagnosis. Chicago, IL; ASCP Press; 1993:197-308.
© Copyright 1995 Pharmacia, Inc.
October 1995
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