Typical immunophenotype of a differentiated AEL includes positivity for glycophorin A and blood group H antigen (precursor structure of ABO blood group substances), negativity for CD45 (common leukocyte antigen), CD34, HLA-DR as weel as myeloid-associated antigens (e.g. CD11b, the myelomonocytic antigen). Immature AEL lacks glycophorin but universally express blood group H antigen and may express CD45, stem cell antigens or selective myeloid antigens. In addition to the erythroid blast cells, a myeloid leukemia component may be present.[4]

Periodic acid-Schiff reaction (PAS) in the cytoplasm of the blast cells from the bone marrow of a patient with acute erythroleukemia (AEL). PAS positive erythroblasts are found in the majority of patients with M6.[1]

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