|
(left) Thin section through the left ventricular wall in a patient with M2, presenting with chloroma in the heart muscle. M2 leukemias with the t(8;21) (q22;q22) translocation have a tendency to form extramedullary tumors. This predisposition may be related to the expression of a neural cell-adhesion molecule, CD56, by the leukemic blast cells.[2] (Left) Other characteristic antigenic features of t(8;21) AML blasts are co-expression of the B-lineage associated antigen CD19 (shown in fluorescence contour plot).[1]
|
