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AML Atlas, Facts & Treatment

AML Atlas, Facts & Trends: M5

"Compared with daunorubicin, idarubicin has a higher lipid coefficient, which results in more rapid cellular uptake8 and stronger binding to DNA9; consequently, the rate of single-strand DNA breaks in tumor cells is higher."[10,11]
-E. Berman, Oncology, 1993.

Acute monocytic leukemia (M5a)

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Blasts with abundant cytoplasm, nuclear indentations and nucleoli.

Translocation t(9;11)(p22;q23) commonly seen in M5a subtype.

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