AML Atlas, Facts & Trends: M4
"Within the AML population, hepatosplenomegaly and lymphadenopathy were more common
(15-20%) in patients with monocytic differentiation (M4, M5)."[5]
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Myeloblasts with mixed eosinophilic and basophilic granules. |
Inversion (pericentric) of chromosome 16, inv(16)(p13;q22), involving CBFB and MYH1 genes. This inversion is usually associated with marrow eosinophilia and a favorable prognosis. |
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