Trends In Blood Component Usage/title> <link rel="stylesheet" type="text/css" href="http://www.meds.com/meds_style.css"> </head> <meta name="keywords" Content="hematology, leukemia, myeloid, myelogenous, Idamycin, idarubicin, lymphoma, thrombosis, heparin, Fragmin, dalteparin"> <body bgcolor="#ffffcc" link="#000099" alink="#ff0000" vlink="#cc0033"> <a name="top"></a> <script language="javascript" type="text/javascript">  </script> <div id="pagewidth">  <p> <center> <table border="0" bgcolor="#31639f" height="56"> <tr> <td> <table border="0"> <tr valign="top"> <td> <table border="0"> <tr valign="top"> <td> <a href="/about.html"><img src="http://www.meds.com/molmime/logos/medslogo_small_98.gif" width="166" height="69" border="0" alt="About Medicine OnLine"></a> </td> <td valign="middle"><a href="/index.html" onMouseOver="loadimage('homespace', 'http://www.meds.com/molmime/stethnav/hns_home.gif'); status='Medicine OnLine Home Page'; return true;" onMouseOut="loadimage('homespace', 'http://www.meds.com/molmime/stethnav/hn_home.gif'); status='Medicine OnLine Home Page'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_home.gif" alt="Medicine OnLine Home Page" width="104" height="23" border="0" name="homespace"></a><a href="/library.html" onMouseOver="loadimage('libraryspace', 'http://www.meds.com/molmime/stethnav/hns_libraries.gif'); status='Cancer Libraries'; return true;" onMouseOut="loadimage('libraryspace', 'http://www.meds.com/molmime/stethnav/hn_libraries.gif'); status='Cancer Libraries'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_libraries.gif" alt="Cancer Libraries" width="104" height="23" border="0" name="libraryspace"></a><a href="/DChome.html" onMouseOver="loadimage('dosecalcspace', 'http://www.meds.com/molmime/stethnav/hns_dosecalc.gif'); status='DoseCalc Online'; return true;" onMouseOut="loadimage('dosecalcspace', 'http://www.meds.com/molmime/stethnav/hn_dosecalc.gif'); status='DoseCalc Online'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_dosecalc.gif" alt="DoseCalc Online" width="104" height="23" border="0" name="dosecalcspace"></a><a href="http://206.35.174.152/eTopics/topic.asp?user=199912271429556.936282E-02&topicid=488" onMouseOver="loadimage('oncologyspace', 'http://www.meds.com/molmime/stethnav/hns_oncology.gif'); status='Oncology News'; return true;" onMouseOut="loadimage('oncologyspace', 'http://www.meds.com/molmime/stethnav/hn_oncology.gif'); status='Oncology News'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_oncology.gif" alt="Oncology News" width="104" height="23" border="0" name="oncologyspace"></a><br><a href="/forums.html" onMouseOver="loadimage('forumspace', 'http://www.meds.com/molmime/stethnav/hns_forums.gif'); status='Cancer Forums'; return true;" onMouseOut="loadimage('forumspace', 'http://www.meds.com/molmime/stethnav/hn_forums.gif'); status='Cancer Forums'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_forums.gif" alt="Cancer Forums" width="104" height="23" border="0" name="forumspace"></a><a href="/pubmedfr1.html" onMouseOver="loadimage('medlinespace', 'http://www.meds.com/molmime/stethnav/hns_medline.gif'); status='Medline Search'; return true;" onMouseOut="loadimage('medlinespace', 'http://www.meds.com/molmime/stethnav/hn_medline.gif'); status='Medline Search'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_medline.gif" alt="Medline Search" width="104" height="23" border="0" name="medlinespace"></a><a href="/cancerlinks.html" onMouseOver="loadimage('linkspace', 'http://www.meds.com/molmime/stethnav/hns_links.gif'); status='Cancer Links'; return true;" onMouseOut="loadimage('linkspace', 'http://www.meds.com/molmime/stethnav/hn_links.gif'); status='Cancer Links'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_links.gif" alt="Cancer Links" width="104" height="23" border="0" name="linkspace"></a><a href="/glossary.html" onMouseOver="loadimage('glossaryspace', 'http://www.meds.com/molmime/stethnav/hns_glossary.gif'); status='Glossary'; return true;" onMouseOut="loadimage('glossaryspace', 'http://www.meds.com/molmime/stethnav/hn_glossary.gif'); status='Glossary'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_glossary.gif" alt="Glossary" width="104" height="23" border="0" name="glossaryspace"></a> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </center> </p>  <br clear="all">    <script type="text/javascript"> </script> <script type="text/javascript" src="http://pagead2.googlesyndication.com/pagead/show_ads.js"> </script>    <br clear="all"> <p> <center> <p><font face="arial,geneva,helvetica" size="2">[ <a href="/conradnotes.html">Conrad Notes Index</a> | <a href="/conrad/ash/ash.html">ASH Index</a> ]</font></p> </center> </p> <p> <center> <img src="http://www.meds.com/molmime/heads/h_conrad.gif" width="196" height="69" border="0" alt="Conrad Notes"> <hr> a timely medical meeting newsletter <hr> <font size="+1">TRENDS IN BLOOD COMPONENT USAGE</font> <hr> </center> <table cellpadding="10"> <tr> <td colspan="2">M.A. Popovsky, MD, American Red Cross Blood Services, Dedham, Mass, examined transfusion data from 182 hospitals serving 10 million people. Seven years' usage (FY'91 through FY'97) showed little change in the number of units of autologous (RCA) and allogeneic (RC) red blood cells used for transfusions. Plateletpheresis (PH) from single donors seemingly replaced some units of pooled platelet concentrate (PC). Cryoprecipitate (CRYO) units fell steadily while administered fresh frozen plasma units (FFP) increased. The results may help blood collection and transfusion services plan future allocation of resources.<p> </td> </tr> <tr> <td valign="top" width="33%"> <b>Background for survey</b> </td> <td width="66%">In Popovsky's view, many changes took place in transfusion practice since the 1989 US nation-wide survey of Wallace and coworkers (<i>Transfusion</i> 1993;<b>33</b>:139-144). Among these changes were the increase in minimally invasive surgery, pharmacologic interventions in surgery, managed care and pressures to cut costs, and use of growth factors to promote the formation of blood cells. The present survey covers a 7-year period to help understand recent trends in blood component usage.<p> </td> </tr> <tr> <td valign="top" width="33%"> <b>Collection of data</b> </td> <td width="66%">This survey used several sources to cover FY'91 through FY'97. The Mass Department of Public Health provided actual transfusion data for the 7-year period. Mathematical modeling allowed application of market share information. In addition, distribution records of all 182 hospitals in Mass, Maine, Vermont and New Hampshire helped provide a database covering 10 million people. </td> </tr> <tr> <td valign="top" width="33%"> <b>New England trends in transfusion usage</b> </td> <td width="66%">As seen below, the use of PC, PH, FFP and CRYO units changed appreciably since FY'91.<p> <center><b>Thousands of Units Used</b><table cellpadding="10" border> <tr><td> </td><td>RCA </td><td align="center">RC </td><td align="center">PC </td><td align="center">PH </td><td align="center">FFP </td><td align="center">CRYO</td></tr> <tr><td>FY'91 </td><td align="center">21 </td><td align="center">424 </td><td align="center">128 </td><td align="center">23 </td><td align="center">85 </td><td align="center">33</td></tr> <tr><td>FY'97 </td><td align="center"> 20 </td><td align="center">422 </td><td align="center"> 84 </td><td align="center">39 </td><td align="center"> 108 </td><td align="center"> 28</td></tr> <tr><td>% Diff. </td><td align="center"> -4 </td><td align="center">-0.5 </td><td align="center"> -34 </td><td align="center">+69 </td><td align="center">+27 </td><td align="center">-15</td></tr> </table></center><p> Intervening years showed some fluctuations in the number of units dispensed. <p> The 34% decrease in PC units may be associated, in part, with the 69% increase in PH units obtained from single donors. According to Popovsky, two developments help account for the decreased use of PC: (1) the rise in intensive chemotherapy and (2) the new transfusion guidelines recommending the initial use of fewer units of PC.<p> FFP administrations increased steadily over the 7 years. This trend occurred despite the introduction of guidelines narrowing the indications for use to plasma exchange and thrombocytopenia purpura.<p> Use of CRYO products (cryoglobulin, antihemophilic factor and other precipitates resulting from cooling) fell 15% since FY'91. Popovsky suggests that approval of Factor VIII for treating von Willebrand's disease may account for the decreased demand for CRYO.<p> </td> </tr> <tr> <td valign="top" width="33%"> <b> Conrad comments</b> </td> <td width="66%">At minimum, the Popovsky survey covering 4 of the 6 New England States merits annual updating and possible expansion to include the entire US. The increased use of more costly units of PH requires further study to identify the added benefit(s).<p> For professional correspondence, please contact Dr. Popovsky by Fax at: (781) 461-2020 or E-mail at: <a href="mailto:Popovsky@Crossnet.org">Popovsky@Crossnet.org</a><p> </td> </tr> </table> <p> <img src="http://www.meds.com/molmime/conrad/conrad_s1.gif" width="300" height="62" alt="Eugene A. Conrad"> <p> Presented at The American Society of Hematology (ASH) Meeting, December 5-9, 1997<br> Copyright © 1998 Conrad Group, Inc. All Rights Reserved<br> Eugene A. Conrad, PhD, MPH / ISSN 1078-2230 / February 1998<br> Send comments to: <a href="mailto:ConradNote@aol.com">ConradNote@aol.com</a> <p> <center> <font face="arial,geneva,helvetica" size="2">[ <a href="#top">Top</a> | <a href="/conradnotes.html">Conrad Notes Index</a> | <a href="/conrad/ash/ash.html">ASH Index</a> ]</font> </center> </p>  <p> <center> <table border="0" bgcolor="#31639f" height="56"> <tr> <td> <table border="0"> <tr valign="top"> <td> <table border="0"> <tr valign="top"> <td> <a href="/about.html"><img src="http://www.meds.com/molmime/logos/medslogo_small_98.gif" width="166" height="69" border="0" alt="About Medicine OnLine"></a> </td> <td valign="middle"><a href="/index.html" onMouseOver="loadimage('home2space', 'http://www.meds.com/molmime/stethnav/hns_home.gif'); status='Medicine OnLine Home Page'; return true;" onMouseOut="loadimage('home2space', 'http://www.meds.com/molmime/stethnav/hn_home.gif'); status='Medicine OnLine Home Page'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_home.gif" alt="Medicine OnLine Home Page" width="104" height="23" border="0" name="home2space"></a><a href="/library.html" onMouseOver="loadimage('library2space', 'http://www.meds.com/molmime/stethnav/hns_libraries.gif'); status='Cancer Libraries'; return true;" onMouseOut="loadimage('library2space', 'http://www.meds.com/molmime/stethnav/hn_libraries.gif'); status='Cancer Libraries'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_libraries.gif" alt="Cancer Libraries" width="104" height="23" border="0" name="library2space"></a><a href="/DChome.html" onMouseOver="loadimage('dosecalc2space', 'http://www.meds.com/molmime/stethnav/hns_dosecalc.gif'); status='DoseCalc Online'; return true;" onMouseOut="loadimage('dosecalc2space', 'http://www.meds.com/molmime/stethnav/hn_dosecalc.gif'); status='DoseCalc Online'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_dosecalc.gif" alt="DoseCalc Online" width="104" height="23" border="0" name="dosecalc2space"></a><a href="http://206.35.174.152/eTopics/topic.asp?user=199912271429556.936282E-02&topicid=488" onMouseOver="loadimage('oncology2space', 'http://www.meds.com/molmime/stethnav/hns_oncology.gif'); status='Oncology News'; return true;" onMouseOut="loadimage('oncology2space', 'http://www.meds.com/molmime/stethnav/hn_oncology.gif'); status='Oncology News'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_oncology.gif" alt="Oncology News" width="104" height="23" border="0" name="oncology2space"></a><br><a href="/forums.html" onMouseOver="loadimage('forum2space', 'http://www.meds.com/molmime/stethnav/hns_forums.gif'); status='Cancer Forums'; return true;" onMouseOut="loadimage('forum2space', 'http://www.meds.com/molmime/stethnav/hn_forums.gif'); status='Cancer Forums'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_forums.gif" alt="Cancer Forums" width="104" height="23" border="0" name="forum2space"></a><a href="/pubmedfr1.html" onMouseOver="loadimage('medline2space', 'http://www.meds.com/molmime/stethnav/hns_medline.gif'); status='Medline Search'; return true;" onMouseOut="loadimage('medline2space', 'http://www.meds.com/molmime/stethnav/hn_medline.gif'); status='Medline Search'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_medline.gif" alt="Medline Search" width="104" height="23" border="0" name="medline2space"></a><a href="/cancerlinks.html" onMouseOver="loadimage('link2space', 'http://www.meds.com/molmime/stethnav/hns_links.gif'); status='Cancer Links'; return true;" onMouseOut="loadimage('link2space', 'http://www.meds.com/molmime/stethnav/hn_links.gif'); status='Cancer Links'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_links.gif" alt="Cancer Links" width="104" height="23" border="0" name="link2space"></a><a href="/glossary.html" onMouseOver="loadimage('glossary2space', 'http://www.meds.com/molmime/stethnav/hns_glossary.gif'); status='Glossary'; return true;" onMouseOut="loadimage('glossary2space', 'http://www.meds.com/molmime/stethnav/hn_glossary.gif'); status='Glossary'; return true;"><img src="http://www.meds.com/molmime/stethnav/hn_glossary.gif" alt="Glossary" width="104" height="23" border="0" name="glossary2space"></a></td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </center> </p>