[MOL] An edge with squalamine [01168] Medicine On Line


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[MOL] An edge with squalamine



Good Day All,

found the following to be in the pipeline.

An edge with squalamine
------------------------
Magainin Pharmaceuticals of Plymouth Meeting, Pa., said that 11 of 36 
patients (31%) with Stage IIIb and IV non-small-cell lung cancer in 
a phase-2a trial responded with partial responses to squalamine given 
in combination with carboplatin and paclitaxel. This compares with a
15% historical response rate to chemotherapy alone, according to
the company. Squalamine is an anti-angiogenic aminosterol, a class of 
small molecules discovered in the dogfish shark, that is also being 
investigated for ovarian cancer, prostate cancer, pediatric solid 
tumors, brain tumors, and fibrodysplasia ossificans progressiva.

God Bless YOu All,
marty auslander
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