[MOL] NSCLC info.... [01327] Medicine On Line

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[MOL] NSCLC info....

Survival Edge in NSCLC for Simultaneous Chemo and Radiotherapy

BOSTON-Concurrent chemotherapy and radiation appears to extend survival in patients with locally advanced non-small-cell lung cancer, the Radiation Therapy Oncology Group reported this week.

In a study of 592 Stage II and III patients, those randomized to platinum-based chemotherapy given at the same time as daily radiation had a 17.1-month median survival, compared with 14.6 months among those treated sequentially. For those whose radiation was delivered twice daily along with chemotherapy, the median survival was 16 months.

A concurrent regimen appears to prevent the accelerated proliferation of resistant cells that often occurs when chemotherapy is given alone prior to radiotherapy, Dr. Ritsuko Komaki of the M.D. Anderson Cancer Center in Houston, speaking for the RTOG, told the American Society for Therapeutic Radiology and Oncology meeting here on Oct. 23.

The regimen of twice-daily radiation with chemotherapy seemed to be the most effective treatment for the 225 patients in the study with squamous-cell carcinoma. Twenty-six percent of the patients getting this regimen failed locally, compared with 38% in the sequential group, and 32% in the group getting daily radiation with chemo.

However, the twice-daily radiation regimen was the most toxic of the three. It led to acute toxicity for 63%, vs. 31% in the sequential group, and 50% among those receiving daily radiation with chemo. Esophagitis was the most common side effect. There was no difference in late toxicities among the three groups.



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