[MOL] Prostate cancer may affect bone density.... [00880] Medicine On Line


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[MOL] Prostate cancer may affect bone density....



Hormone-suppressing Prostate Cancer Treatment May Affect Bone Density

A DGReview of :"Incidence of bone fracture in patients receiving luteinizing hormone-releasing hormone agonists for prostate cancer"
British Journal of Urology

10/03/2000
By Mark Greener


Prostate cancer patients undergoing chronic treatment with luteinizing hormone-releasing hormone agonists should have their bone mineral density and levels of bone metabolic markers measured periodically, Japanese researchers advise.

Chronic treatment with luteinizing hormone-releasing hormone agonists (LHRH-a) for prostate cancer lowers testosterone levels and reduces bone mineral density. This increases the risk of secondary osteoporosis.

Researchers in Tokyo and Kanagawa enrolled 218 prostate cancer patients treated for at least six months with LHRH-a. Of these, six percent suffered a bone fracture during LHRH-a administration, on average 28 months from the start of treatment. No patient experienced a fracture at a metastasitic site.

The authors measured bone density in the third lumbar vertebra using quantitative computed tomography. They also measured the following metabolic markers: osteocalcin, 1,25-(OH)2 vitamin D, urinary type 1 collagen cross-linked N-telopeptides, parathyroid hormone and calcitonin.

Bone density was significantly lower in patients who had a fracture than in those who did not. Moreover, levels of urinary type 1 collagen cross-linked N-telopeptides was higher in those who had a fracture.

The authors conclude that patients receiving long-term LHRH-a for prostate cancer require periodic measurement of bone mineral density and bone metabolic markers. Such patients also need to be evaluated for secondary osteoporosis.

 
 
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