[MOL] Researchers say cyanide could be cancer killer..... [00407] Medicine On Line

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[MOL] Researchers say cyanide could be cancer killer.....

Wednesday, September 06, 2000
Researchers say cyanide could be cancer-killer

LONDON, Sep 06 (Reuters) - The deadly poison cyanide may have a role as a powerful cancer killer, British scientists said Wednesday.

Researchers at London's Imperial College told a science meeting that they had harnessed a cyanide-generating system used by plants as a defense against insects and believed the mechanism could be developed to produce anti-cancer drugs. Plants like the hydrangea and African potato contain an enzyme called linamarase that is capable of generating cyanide when they are damaged by animals or insects.

The scientists believe they can attach that enzyme to a cancer-seeking antibody capable of recognizing a protein found only in certain cancers. The method--known as AGENT (Antibody Guided Enzyme Nitrile Therapy)--would produce an agent that could potentially kill cancer cells and leave healthy tissue unharmed.

Dr. Mahendra Deonarain of Imperial College's Department of Biochemistry told the British Association's Festival of Science meeting in London that the work was still at an early stage but was promising.

"We have demonstrated that this system is able to specifically kill tumor cells by cyanide intoxication,'' he said. "The next step is to identify the best molecule to proceed before we go on to animal studies.''

Despite the deadly nature of cyanide, the amount generated by the technique is only sufficient to kill the specific cancer cell targeted by the combined enzyme-antibody molecule. A natural enzyme produced in the human liver should detoxify any cyanide that leaks away from the tumor.

The research has been submitted for publication in the British Medical Journal.

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