[MOL] Bacterial Protein Shows Promise for Cancer Vaccine [00264] Medicine On Line

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[MOL] Bacterial Protein Shows Promise for Cancer Vaccine

Bacterial Protein Shows Promise for Cancer Vaccine
    [09/05/2000; PR Newswire]

PARIS and CAMBRIDGE, Mass., Sept. 5 /PRNewswire/ -- A non-toxic
form of a bacterial protein known as Shiga B-subunit together
with tumor associated molecules can stimulate the immune system of
mice to attack cancer cells without the need for secondary compounds
known as adjuvants and offers hope for the development of improved
cancer vaccines, according to a study published in the September
issue of the Journal of Immunology. The non-toxic B-subunit of Shiga
toxin binds to specific receptors found on dendritic cells in vivo
and in vitro, acting as a specific carrier molecule for tumor associated
antigens. The combination of the B-subunit and tumor associated
antigens causes dendritic cells to activate tumor killing white blood

Dendritic cells are one of the first respondants of the immune system
which, if stimulated to recognize tumor-associated molecules known
as antigens, can activate white blood cells such as T Lymphocytes to
recognize and kill tumor cells.

``This is an important step forward in the development of a cancer
vaccine because the results show that the non-toxic B-subunit fused
to tumor associated antigens stimulates cancer-fighting cells in vivo
without the need for an adjuvant,'' said Eric Tartour, M.D., Ph.D.
at the University Pierre and Marie Curie (UPMC).

The full article can be found at:


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