RE: [MOL] DNA, Aging and Cancer, Part 1.... [00171] Medicine On Line

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RE: [MOL] DNA, Aging and Cancer, Part 1....

I have been reading a book called one renegade cell.  The entire basis of
this book centres on the fact that cancer, though generally viewed as an
"invader" in the body, does in fact get generated by DNA and cell
regeneration getting its codes confused.  It is a very interesting book, and
certainly made me sit back and think more deeply about the changes in the
human body that "creates" cancerous cells.  Off hand, I can not remember the
name of the author, but the book is available from Amazon.

-----Original Message-----
From: Lillian []
Sent: 03 May 2000 18:30
To: Nancy J.
Subject: [MOL] DNA, Aging and Cancer, Part 1....

DNA, Aging and Cancer, Part 1 
by: Darryl See M.D. and Ferre Akbarpour, M.D. 

Excerpt from the soon to be released book Anti-Aging: The Quest to End Aging

DNA is the fundamental molecule of life. It occurs in all cells. DNA stores
genetic information in double helical chains that wind about each other like
a double spiral staircase. Its structure is similar to that of the caduceus:
the winged staff with two serpents twined about it, carried by the Greek god
Hermes and used as the symbol of the medical profession. 

Pairs of four different bases-adenine, paired always with thymine, and
cytosine, paired always with guanine-form the steps that link the two
intertwined strands. These four bases, or nucleotides, as they are often
called, are usually abbreviated "A and T," "C and G." 

The four nucleotides can appear in any sequence or order, and one or more of
them may be repeated any number of times, as long as each is always paired
with its partner in the complementary strand. The number of different
combinations that can be expressed, or created, in this four-letter alphabet
is virtually unlimited: four to the Nth power, where N is the number of base
pairs. Considering that the DNA in human cells contains about three billion
base pairs, this gives us a potential of different possible DNA combinations
as four raised to the three-billionth power -a very large number indeed. 

When wound around itself many times (super-coiled), DNA takes on a sort of
crooked sausage shape we call a chromosome-the basic unit of heredity. All
somatic human cells have 46 chromosomes. One set of 22 is inherited from the
mother; a matching set comes from the father. An additional pair of
chromosomes determines the sex of the baby. An XX combination results in a
girl; an XY pairing results in a boy. 

DNA holds the instructions for the proteins necessary for creating and
maintaining life. The segment of DNA that specifies (codes for) one complete
protein is called a gene. 

Proteins are made of amino acids. The type of protein that is created by a
group of amino acids is determined by their order in its formation. The
order of amino acids is specified by the sequence, or order, of consecutive
groups of three-nucleotide units, called triplets or codons, found within
the gene for that protein. For example, the triplet CCT is the code for the
amino acid glycine. CAA is the codon for the amino acid valine. AGA codes
for serine. And so on, until the sequence of amino acids that determines the
primary structure of the protein is complete. Ultimately, this amino acid
sequence determines the three-dimensional shape (and hence the function) of
the protein molecule. 

The process continues. The next gene holds the genetic code for the next
protein. And so on, for the next protein, and the next, until every single
atom of every single protein that comprises an organism has been completely
and precisely specified. This complete set of genes is like a library that
holds a blueprint, or recipe, for making each kind of molecule the organism
needs. It is its genome. 

What has all this to do with cancer or aging? Well, quite a lot, as it turns
We invite you to take a look at our Album.
  ( Very informational, good tips, Molers pictures, art work and much

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