Looks like chocolate may not be the ONLY good thing coming out of Hershey,
PA! Love, Joicy
Researchers Stop Cancer Spreading in Mice
[04/25/2000; Reuters News Service]
NEW YORK (Reuters Health) - Replacing lost genetic material
in cancer cells may prevent them from growing in secondary
sites, research in mice suggests.
With most cancers, it is not the first tumor that is most deadly,
but when the disease starts spreading to other body parts, a
process called metastasis. In experiments with human skin cancer
cells placed into mice, researchers found that restoring chromosome
6 in the cancer cells stopped them from growing into the animals'
lungs. Dr. Danny R. Welch, an associate professor of pathology
at Pennsylvania State University College of Medicine in Hershey,
led the study. He reported the findings recently in San Francisco
at the annual meeting of the American Association for Cancer
Research. Portions of chromosome 6 are missing in 70% to 80% of
cases in which melanoma spreads beyond the skin, Welch told Reuters
Health. Knowing this, he and his colleagues placed two sets of
human melanoma cells in mice -- one with a defective chromosome
6 and one in which the chromosome was restored. Over months,
the defective cells spread to the lungs and generated tumors;
in contrast, cells with the restored chromosome 6 spread to the
lungs but did not grow. ``They just sit there dormant,'' Welch
said, adding that other researchers have recently shown that
manipulating chromosome 17 in prostate cancer cells keeps them
from growing at other sites.
The full article can be found at:
http://dailynews.yahoo.com/h/nm/20000425/hl/cancer_mice_1.html
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