[MOL] Preserving Brain Cells [01559] Medicine On Line


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[MOL] Preserving Brain Cells



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marty auslander
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Preserving Your Brain Cells

By Betty Kamen, PhD

Although no one looks forward to getting older—with concomitant skin sagging, eyes drooping, shoulders hunching, or chins doubling—our worst aging fear is "losing our marbles." With the incidence of Alzheimer's disease increasing, this concern is well founded. We know that the paradigm applies to brain cells, but now we have even more proof that a stimulating environment can protect against brain cell death, especially the kind that commonly accompanies aging. An experiment with test animals (rats) showed that those housed in an exciting or enriched environment were almost completely protected when exposed to a seizure-promoting toxic agent. Autopsy confirmed that the actual brain cells in the hippocampus region of the brain were protected from destruction in these animals. (The hippocampus is the portion of the brain essential for initial storing of long-term memory.)

The "enriched" environment for the test animal included running wheels, tunnels, balls, and choices of food. No, that doesn't mean we should head for the nearest amusement park to stave off brain cell death. For us, this research translates to learning experiences— attending classes, learning to play bridge—any activity that stimulates our brain cells (Nature Medicine 1999; 5:448-453). Accumulating evidence shows that hippocampal disruption is an early feature of Alzheimer's disease. (Journal of the American Medical Association 1999; 281:1401-1406)