[MOL] The Role of Natural Killer Cells in Viral Infections [01380] Medicine On Line

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[MOL] The Role of Natural Killer Cells in Viral Infections

Good Morning All,

Thought this information might be educational and useful in the fight to
strengthen our immune systems. To me, in my opinion, the prime function
in fighting this disease is to empower by knowledge and education the
ability to strengthen the immune system to a point where it fights
cancer cells on its own in order to reach our goals to wellness. Of
course that is one of the methods, but highly important. Again, my

The Role of Natural Killer Cells in Viral Infections

Natural killer (NK) cells are large granular lymphocytes 
that lyse tumor or virus-infected cells. Mounting evidence 
suggests that these cells are important in the early 
response of the immune system to many viral infections [1]. 
Although acquired deficiency in NK function has been 
described in the chronic fatigue syndrome (CFS) [2], human 
immunodeficiency virus (HIV) infection [3], metastatic 
carcinoma [4], autoimmune disorders [5], depression [6]and 
exposure to occupational chemicals [7]; the clinical 
significance of the reduced NK function in these disorders 
has not been established. The Chediak-Higachi syndrome [8]
and leucocyte adhesion deficiency [9]are genetic disorders 
characterized by profiles of depressed immune response, 
each of which includes a depression of NK-cells function. 
Patients with these disorders suffer from severe, recurrent 
infections, haematological malignancies and early 
mortality. In the present review, the basic immunology of 
NK cells, the importance of NK function as derived from 
viral infections in animals and the role of NK cells in 
specific viral infections in humans are discussed. Other 
human conditions associated with lymphocytes. A functional 
classification of lymphocytes can further distinguish B 
cells, T cells and NK cells, utilizing the expression of 
specific cell surface glycoproteins and/or the specific 
mechanism by which the cell protects the host from foreign 
antigens. NK cells are larger than most B or T cells, 
ranging in diameter from 12 to 15 um. They originate and 
differentiate in the bone marrow, and they ultimately 
represent 5-10% of the total mononuclear cells in the 
blood. Characteristics of these cells include a kidney-
shaped nucleus and abundant cytoplasm containing numerous 
azurophilic granules. They are non-adherent cells. Most 
express the surface glycoprotein marker CD2 (sheep red 
blood cell receptor), CD16 (Fc receptor), CD45 (leucocyte 
common antigen), CD56 (NCAM), CD57, CD11a/CD18 (lymphokine 
function-associated antigen-1 LFA-1), CD11b/CD18 (Mac-1) 
and CD11c/CD18 (p150,95) [10,11]. Some also express the T-
cell markers CD7, CD8 and CD38. NK cells are often 
distinguished from other mononuclear cell populations by 
the presence of CD16 and CD56 molecules in the absence of 


God Bless YOu All,
marty auslander
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