[MOL] Osteoporosis Due to Cancer Treatment [02394] Medicine On Line


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[MOL] Osteoporosis Due to Cancer Treatment



Osteoporosis Due to Cancer Treatment: Pathogenesis and
    Management 
    [03/30/2000; Journal of Clinical Oncology]

ABSTRACT: Many therapeutic regimens in cancer treatment carry
the risk of causing or favoring the development of osteoporosis.
Therapies in which hypogonadism may occur are most relevant in
this respect. Prompt hormone replacement therapy is indicated
in these patients. In patients in whom this is undesirable because
of a hormone-dependent tumor, the risk of osteoporosis should
be assessed by means of osteodensitometry, and prophylactic or
therapeutic measures should be instituted if necessary. Early
intervention improves outcome because osteoporosis therapy is
most effective in preventing deterioration of bone mass. There
remains much uncertainty in assessing the risk of combination
chemotherapy with regard to the development of osteoporosis.
Negative effects on the skeleton have, however, been demonstrated
for individual drugs, such as methotrexate and ifosfamide. Negative
effects of the tumor itself on bone metabolism may aggravate
the degree of osteoporosis. Detailed data and long-term experience
to assess the risk are urgently needed in this area and constitute
an important research topic for the coming years and decades.
This review discusses the most prevalent mechanisms of osteoporosis
caused by cancer treatment and outlines therapeutic strategies
for the prevention and treatment of therapy-induced bone loss.

The full article can be found at:

http://www.jco.org/cgi/content/abstract/18/7/1570
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