Re: [MOL] Inflammation linked to ovarian cancer risk..... [00880] Medicine On Line

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Re: [MOL] Inflammation linked to ovarian cancer risk.....

Dear Lil,

Good Info lil. thanks.

God Bless you,
marty and Barb

> Lillian wrote:
> Inflammation linked to ovarian cancer risk
> NEW YORK, Mar 08 (Reuters Health) -- Factors that cause inflammation
> in the lining of the ovaries -- such as endometriosis, or even
> powdering with talc -- increase the risk of ovarian cancer, according
> to researchers at the University of Pittsburgh, Pennsylvania. But the
> team also reports that gynecologic surgery, such as the female
> sterilization procedure tubal ligation, greatly reduces a woman`s risk
> of developing the cancer.
> In a study of more than 2,000 women aged 20 to 69, investigators found
> that those with a history of endometriosis, ovarian cysts, or
> overactive thyroid were at increased risk for ovarian cancer. Talc
> use, which may spur inflammation in the ovarian lining, also elevated
> cancer risk. A team led by Roberta B. Ness, of the Graduate School of
> Public Health, reports the findings in the March issue of
> Epidemiology.
> Certain factors that suppress ovulation and hormones that affect the
> ovaries -- such as pregnancy, birth control pill use, and
> breastfeeding -- have widely been found to protect against ovarian
> cancer. Yet the risk related to ovarian inflammation is less well
> understood, according to Ness and her colleagues. Inflammation, they
> note, produces toxic oxidants that inflict genetic damage in cells, a
> process that may lead to cell changes and cancer.
> In interviews with women with and without ovarian cancer, the study
> authors found that, as expected, pregnancy and breastfeeding reduced
> cancer risk. In addition, the team found a 50% decrease in risk with a
> first pregnancy and small dips with each subsequent pregnancy. Oral
> contraceptives also lowered cancer risk when used for at least one
> year.
> The Pittsburgh researchers then questioned the women on factors that
> can trigger ovarian inflammation. Three medical conditions were found
> to increase cancer risk, relative to women without the conditions:
> ovarian cysts, growths on the ovaries that can be harmless or
> dangerous, increased cancer risk by 30%; a 70% higher risk was linked
> to endometriosis, a condition in which pieces of the uterine lining
> grow outside of the uterus; and hyperthyroidism, a disorder marked by
> overproduction of thyroid hormones, was linked to an 80% higher risk
> of ovarian cancer.
> Both endometriosis and ovarian cysts may trigger local inflammation,
> and both have been linked to ovarian cancer in previous studies, Ness
> and colleagues note. This study is the first, however, to connect
> hyperthyroidism and ovarian cancer. Hyperthyroidism, the researchers
> explain, often results from the immune system`s assault on the thyroid
> gland; such autoimmune diseases are systemic and can trigger
> widespread inflammation.
> As in numerous other studies, women who used talc anywhere on their
> bodies or in their underwear showed an elevated cancer risk, even when
> risk factors such as family history of ovarian cancer were considered.
> One condition that causes ovarian inflammation, pelvic inflammatory
> disease, was linked to only a slight incline in cancer risk. Other
> studies, the authors note, have shown a stronger link.
> Having had a hysterectomy or a tubal ligation helped protect women
> from ovarian cancer. These procedures, the researchers explain, cut
> off the path between the lower and upper genital tract, blocking
> inflammatory substances from gaining access to the ovarian lining.
> SOURCE: Epidemiology 2000;11:111-117.
> [Image]
> Warmly, lillian
> We invite you to take a look at our
> Album.
>   ( Very informational, good tips, Molers pictures, art work and much
> more....
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