A new test has been shown effective for detecting bladder cancer and
evaluating its grade. The hyaluronic acid-hyaluronidase test is noninvasive,
highly sensitive and specific, researchers report.
Urine specimens from
513 patients were examined -- 261 from transitional cell carcinoma (TCC)
patients, nine from patients with non-TCC tumours and 243 from controls.
Controls were normals, patients with other genitourinary (GU) conditions or a
history of bladder cancer.
Urinary hyaluronic (HA) levels were elevated
from 2.5 to 6.5-fold in bladder cancer patients as compared with normals, GU
patients and patients with a bladder cancer history. Urinary hyaluronidase
(HAase) levels were also higher in G2/G3 patients than in normals and patients
with GU conditions, history of bladder cancer or G1 tumours.
urine test detected bladder cancers, regardless of tumour grade and stage, with
higher sensitivity and accuracy and comparable specificity, the researchers