[MOL] Test Spots and grades of bladder cancer... [00057] Medicine On Line

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[MOL] Test Spots and grades of bladder cancer...





Test Spots And Grades Bladder Cancer

A DGReview of :"Urinary hyaluronic acid and hyaluronidase markers for bladder cancer detection and evaluation of grade"
Journal of Urology

By Anne MacLennan

A new test has been shown effective for detecting bladder cancer and evaluating its grade. The hyaluronic acid-hyaluronidase test is noninvasive, highly sensitive and specific, researchers report.

Urine specimens from 513 patients were examined -- 261 from transitional cell carcinoma (TCC) patients, nine from patients with non-TCC tumours and 243 from controls. Controls were normals, patients with other genitourinary (GU) conditions or a history of bladder cancer.

Urinary hyaluronic (HA) levels were elevated from 2.5 to 6.5-fold in bladder cancer patients as compared with normals, GU patients and patients with a bladder cancer history. Urinary hyaluronidase (HAase) levels were also higher in G2/G3 patients than in normals and patients with GU conditions, history of bladder cancer or G1 tumours.

The HA-HAase urine test detected bladder cancers, regardless of tumour grade and stage, with higher sensitivity and accuracy and comparable specificity, the researchers concluded.Warmly, lillian

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