[MOL] Re: Pet Scans Info. and sites..... [00415] Medicine On Line

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[MOL] Re: Pet Scans Info. and sites.....

ACS MEETING: PET May Predict Success Rates Of Cancer Therapy Before



DALLAS, TX -- March 30, 1998 -- Researchers are a step closer to predicting
how well antiestrogen therapies, such as Tamoxifen, will treat cancer in
individual patients thanks to new radiotracer chemicals developed at
Washington University Medical School in St. Louis.

Chemist Michael J. Welch, Ph.D., presented his findings yesterday at the
national meeting of the American Chemical society.

"Our data suggest that we can now tell an oncologist whether antiestrogen
therapy will work for a particular person before that person begins
treatment," Welch said.

His work uses the technique of positron emission tomography (PET), which
relies on short-lived, radioactive chemicals that emit bursts of energy as
they decay. Scientists use these chemicals to harmlessly tag substances and
trace their effect in the body through PET scan images.

Welch and his colleagues tagged estradiol, a natural estrogen, with the
radiotracer fluorine-18 and, prior to treatment with the antiestrogen drug
Tamoxifen, injected the substance into 10 patients with breast cancer. With
one exception, he said, patients whose PET scans showed high uptake of the
tagged estradiol by their bodies' estrogen receptors responded to the
antiestrogen therapy -- their tumours shrank.

Radiation is another common therapy for cancer. Radiation is less effective
against tumours that are poorly oxygenated, a condition called hypoxia.
Welch's group has developed copper-based radiotracers that may soon allow
oncologists to assess the degree of tumour hypoxia in their patients.

Using the radiotracer chemical copper-60, the researchers tagged substances
that are preferentially taken up by tumour tissue. In animal studies, the
copper complex became trapped in hypoxic tissue, but quickly washed out of
healthy tissue. The hypoxic tumours -- those that would respond well to
radiation therapy-- showed up strongly on a PET scan. Copper-61 and
copper-64 are two other radiotracer chemicals under study by Welch's group.
Each radiotracer has a different half-life, ranging from about 23 minutes in
the case of copper-60 to more than 12 hours for copper-61. This makes them
useful for different kinds of biomedical imaging.

Some more sites to go too.

http://www.icppet.org/sitelist.html  - Locations of Pet Scans.

http://www.icppet.org/image.html - More good information.

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