[MOL] Antibody-targeted chemotherapy induces remission in some leukemia [00809] Medicine On Line


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[MOL] Antibody-targeted chemotherapy induces remission in some leukemia patients.....



Antibody-targeted Chemotherapy Induces Remission in Some Leukemia Patients

NEW ORLEANS, LA—At the 41st Annual Meeting and Exposition of the American Society of Hematology (ASH) recently, scientists presented the latest data on the use of a pioneering drug technology known as "antibody-targeted chemotherapy" to fight acute myeloid leukemia (AML), a virulent and often fatal form of cancer. The experimental agent, CMA-676, induces remission in a significant proportion of patients with few serious side effects. CMA-676 represents the first successful application of antibody-targeted chemotherapy. AML is an aggressive, life-threatening disease in which certain white blood cells become cancerous and rapidly accumulate in the bone marrow, preventing normal marrow from growing and functioning properly. AML is among the most serious forms of adult leukemia, with a relatively high fatality rate. Most patients require intensive chemotherapy to achieve complete remission, and some also must undergo bone marrow transplants. Up to half of all patients with AML, even after intensive treatment, have residual leukemic cells or experience a relapse.

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