[MOL] Celebrex May help rare cancer... [00766] Medicine On Line


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[MOL] Celebrex May help rare cancer...



Celebrex May Help Rare Cancer

      The Food and Drug Administration has approved an arthritis drug to help treat a rare genetic intestinal disorder.
      Celebrex, a Cox-2 selective nonsteroidal anti-inflammatory drug commonly used to treat arthritis, can reduce the number of colorectal polyps associated with familial adenomatous polyposis. Patients with FAP develop large numbers of polyps, which increase their risk of developing colon cancer or rectal cancer (see Colorectal Cancer) at a young age.
      The FDA says Celebrex should be used only in conjunction with standard care for FAP, which usually includes surgery to remove all or part of the lower intestine in young adults and continued monitoring of the remaining intestinal tissue.
      The FDA accelerated approval for Celebrex based on a six-month, placebo-controlled trial in 83 patients that showed a 28 percent reduction in the number of polyps in Celebrex patients compared with a 5 percent reduction in placebo patients. The most common side effects were diarrhea and indigestion.
      Because the study did not show the clinical benefit of reduced colorectal polyps, or whether the effect of Celebrex will last after use is discontinued, the FDA is requiring the manufacturer to conduct further testing.

Warmly, lillian
 
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