[MOL] Erectile Dysfunction..... [00762] Medicine On Line

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[MOL] Erectile Dysfunction.....

Medscape Urology

MEDLINE Abstracts
Second Therapy for Erectile Dysfunction

What's new in second-line therapy for erectile dysfunction? Find out in this easy-to-navigate collection of recent MEDLINE abstracts compiled by the editors at Medscape Urology. [Medscape, 1999. 1999 Medscape, Inc.]

Back Male Impotence

Morgentaler A
Lancet 1999 Nov 13;354(9191):1713-8

Erectile dysfunction can be devastating for men and for their partners. A good sexual history and focused physical examination can provide clues as to whether the underlying cause is psychogenic or organic. Diagnostic investigation should be tailored to the clinical picture. Oral medications now represent first-line therapy. Penile injection therapy and vacuum constrictive devices are reasonable choices for men in whom oral therapy fails or is contraindicated. The penile prosthesis provides a reliable long-term solution with high satisfaction rates. Psychotherapy may be indicated. Physicians can have a positive impact on the quality of life of patients by providing a non-judgmental and supportive environment for discussion and management of impotence.

Back Vacuum Constriction Devices for Erectile Dysfunction: A Long-term, Prospective Study of Patients With Mild, Moderate, and Severe Dysfunction

Dutta TC, Eid JF
Urology 1999 Nov;54(5):891-3

Objectives: To evaluate, using a long-term, prospective study, the satisfaction rate, attrition rate, and follow-up treatment of well-trained patients using an external vacuum erection device, the Osbon ErecAid System, in the treatment of mild, moderate, and severe organic erectile dysfunction.
Methods: One hundred twenty-nine patients were assessed to determine the severity and cause of their erectile dysfunction. Patients with organic erectile dysfunction who were interested in the Osbon ErecAid received the device after thorough training. Patients received a follow-up questionnaire regarding satisfaction, months of use, reasons for discontinuing, and further treatment.
Results: Our attrition rate was 65% overall and was lowest among patients with moderate erectile dysfunction (55%). All patients with mild dysfunction discontinued use, and a large number (70%) of patients with complete dysfunction also discontinued use. Of the patients who discontinued, most stopped treatment early (median 1 month, mean 4 months) and 63% did not seek further treatment. Thirty-five percent of patients were satisfied with the device and have continued to use it long term (mean 37 months).
Conclusions: Our study showed a lower success rate than previous reports. Patients who were satisfied with the Osbon ErecAid continued to use it for long periods. Patients who were not satisfied dropped out very quickly, and many did not seek further treatment. Patients with moderate erectile dysfunction had a higher rate of success than patients with mild or severe erectile dysfunction.

Back The Causes of Patient Dropout From Penile Self-Injection Therapy for Impotence

Mulhall JP, Jahoda AE, Cairney M, Goldstein B, Leitzes R, Woods J, Payton T, Krane RJ, Goldstein I
J Urol 1999 Oct;162(4):1291-4

Purpose: Penile self-injection therapy, a second line treatment for erectile dysfunction, is the most efficacious means of reestablishing functional erections when first line therapies fail and the patient wants to avoid penile prosthesis implantation. Despite high efficacy rates, injection therapy has high dropout rates. To our knowledge studies to date analyzing patient attrition have reviewed small numbers of patients followed for only short periods. We elucidate the main reasons for patient dropout in a large penile self-injection program with long-term followup.
Materials And Methods: A questionnaire was mailed to 1,424 patients who completed the office training and home use phases of a penile self-injection program.
Results: The overall attrition rate was 31% of the 720 men who completed the questionnaire, with a mean followup of 38 months. The main reasons for dropout were cost of therapy, patient and partner problems with the concept of penile injection, lack of partner availability and spontaneous improvement in erections. Lack of efficacy of therapy was the primary reason for only 1 of 7 dropouts. Furthermore, adverse effects of penile injections (priapism, penile nodules, pain) appeared to be only minor contributors to dropout.
Conclusions: To our knowledge this study is the largest published, single center cohort of patients treated with injection and followed for an analysis of dropout rates. Based on study data a reduction in dropout rates may be achieved by keeping the cost of therapy low, and ensuring patient and partner education as well as continued support throughout treatment.

Back Comparison of Mechanical Reliability of Original and Enhanced Mentor Alpha I Penile Prosthesis

Wilson SK, Cleves MA, Delk JR 2nd
J Urol 1999 Sep;162(3 Pt 1):715-8

Purpose: We report the results of a prospective study of 1,381 Mentor Alpha I penile prostheses implanted to treat impotence, and compare original and enhanced penile prosthesis mechanical reliability.
Materials And Methods: The study consisted of 410 original models manufactured before November 1992 and 971 enhanced models manufactured since December 1992. Implants were further stratified as first time (virgin) or replacements of a previous implant. Mechanical failure-free survival rates for the original prosthetic and enhanced models were compared.
Results: The 5-year survival rate increased from 75.3% for the original to 92.6% for the enhanced model overall (log rank p<0.0001), and from 75.3 to 93.6%, respectively, for the virgin implants only (log rank p<0.0001). The estimated failure rate of approximately 5.6% for the original model was fairly consistent during followup, while the significantly lower failure rate of 1.3% for the enhanced model was not. The failure rate of the enhanced model implants was about 0.8% per year during the first 3.5 years and increased to approximately 3.1% per year thereafter.
Conclusions: Our results strongly support the premise that mechanical reliability is superior with the enhanced compared to the original model.

Back Reasons for Discontinuing Intracavernous Injection Therapy With Prostaglandin E1 (Alprostadil)

Lehmann K, Casella R, Blochlinger A, Gasser TC
Urology 1999 Feb;53(2):397-400

Objectives: To clarify the reasons why experience with self-injection therapy for erectile dysfunction shows high dropout rates. METHODS:We studied 86 patients 36 to 76 years old who had been on home treatment for at least 3 months. Sixty-nine patients (80%) were continuing to use injections, and 17 (20%) had discontinued the treatment. Patients were evaluated by interview and clinical examination.
Results: Patients still in the program used one injection every 2 weeks, and those who had given up treatment had used one injection in 3 weeks (P = 0.31). They were in the program for 3927 and 1622 months (P = 0.002), respectively, and had used 50 (95% confidence interval [CI] 21 to 91) versus 12 (95% CI 4 to 20) injections, respectively (P<0.0001). Injections producing unsatisfactory penile rigidity, prolonged erections, hematoma at injection site, corporal fibrosis, secondary penile deviation, and mean estimated duration of a pharmacoinduced erection showed no significant differences. Patient satisfaction (P = 0.02), estimated partner satisfaction (P = 0.02), increase in self-esteem (P = 0.01), and negligible effort in performing injections (P = 0.001) all showed significantly better results for those still in the program.
Conclusions: Reasons for dropout from self-injection therapy are not based on objective side effects and discomfort. Patients leaving the program are less motivated, less satisfied with the quality of pharmacoinduced sexuality, consider the effort to perform injections to be substantial, and have not achieved improved self-esteem.

Back Endothelial Cell Transplantation Into the Corpus Cavernosum: Moving Towards Cell-Based Gene Therapy

Wessells H, Williams SK
J Urol 1999 Dec;162(6):2162-4

Purpose: As a first step toward a cell based gene therapy for erectile dysfunction, we transplanted fluorescently labeled autologous microvessel endothelial cells (MVEC) into the rat corpus cavernosum.
Materials and Methods: MVEC were isolated from the epididymal fat pad, labeled with the membrane intercalating dye PKH 26, and injected into the corpus cavernosum. Two to 15 days after transplantation the penises were removed, cryosectioned, and examined under epifluorescent and phase contrast microscopy.
Results: In 7 consecutive animals transplanted fluorescent cells were identified in the corpora cavernosa. Bilateral distribution was noted in each animal, and staining with ED1 determined that the fluorescence was not due to engulfment of the MVEC by phagocytic cells.
Conclusion: Transplanted endothelial cells adhere and persist in the corporal sinusoids and provide a rationale for cell-based gene therapy in the penis.

Warmly, lillian
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