[MOL] New ingredient completes marrow recipe [00434] Medicine On Line


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[MOL] New ingredient completes marrow recipe



Subject: New ingredient completes marrow recipe



Dear Folks,



The following is very interesting:



Researchers working with mice have now discovered a way to propagate

blood stem cells in the laboratory by adding thrombopoietin. Prior to

this discovery, stem cells previously died off in a few weeks.



If this method works for human blood cells, it would likely be a

windfall for the treatment of cancer and genetic disorders, and of

course MPDs.



Full details are in the July 6 PROCEEDING OF THE NATIONAL ACADEMY OF

SCIENCES.



New ingredient completes marrow recipe



  Researchers have successfully cultivated blood stem cells‹the cells

that give rise to all blood cells‹over a long period in the laboratory

for the

  first time.



  References:



         Yagi, M. ... and S. Bartelmez. 1999. Sustained ex vivo

expansion of hematopoietic stem cells mediated by thrombopoietin.

         Proceedings of the National Academy of Sciences 96(July

6):8126.



  Further Readings:



         Seppa, N. 1998. Making use of mismatched donor marrow. Science

News 154(Oct. 26):261.



         Travis, J. 1998. Bone marrow cells can build new muscle.

Science News 153(March 7):150.



  Sources:



         Stephen H. Bartelmez

         Seattle Biomedical Research Institute

         Department of Pathobiology

         4 Nickerson Street

         Seattle, WA 98109



  From Science News, Vol. 156, No. 3, July 17, 1999, p. 37. Copyright ©

1999, Science Service.



God Bless You All,

marty auslander
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