[MOL] Bone Marrow Stem Cells Identified [00427] Medicine On Line


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[MOL] Bone Marrow Stem Cells Identified



Subject: Bone Marrow Stem Cells Identified



Bone Marrow Stem Cells Identified



 September 3, 1999



WASHINGTON - AP - Researchers have found a way to identify and isolate

special stem cells in the bone marrow, a development that could lead to

new treatments for blood diseases.



Scientists at Jefferson Medical College report on Friday in the journal

Science that hematopoietic stem cells have a protein marker, called KDR,

that can be used as sort of a beacon to isolate them from other,

similar-looking cells.



The stem cells are made in the bone marrow. They can develop into any

kind of blood cell and can reproduce endlessly.



Researchers believe if the stem cell can be isolated and cultured in the

laboratory, it could be used to grow red, white and platelet blood

cells, all of which have important medical applications. For instance,

it is believed the stem cell could be used to produce blood for

transfusions or cells for bone marrow transplants.



But the stem cells are rare, making up only one of every 100,000 cells

in the bone marrow. Researchers have had trouble isolating them from

other bone marrow cells that they closely resemble.



Now the technique developed by a Jefferson team led by Dr. Cesare

Peschle may have solved that problem.



The researchers have found an antibody that they can use to separate the

valuable stem cells from the other cells in the bone marrow. Repeated

use of the technique allows the stem cells to be concentrated into

useful numbers, the researchers report.



God Bless All,

marty auslande
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