RE: [MOL] Antineoplastin Therapy [01139] Medicine On Line

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RE: [MOL] Antineoplastin Therapy

Dear Francisco:  Never apologize for your English!!!!  It's excellent.  You
should hear my Spanish!  It's horrible.  You are a good friend to be so
concerned about your friend's mother.  I hope we've been able to help you.
Your friend, Kathy in Boise  

-----Original Message-----
<>  [
<> ]On Behalf Of Francisco José Millán
Sent: Friday, October 29, 1999 9:35 AM
To: <> 
Subject: RE: [MOL] Antineoplastin Therapy

Dear Sr.

    This is the first time that I try to send some information to the MOL
list from where I've found information for my the mother of my friend, and
many people wishing to help (thanks Lillian, Kate, Jeanne, and I'm sorry
because for the people I do not mention since I don't remember their names,
the people that have tried to help my friend's mother in any way), I hope
this could help in any way you. i have copied the information about
ANTINEOPLASTIN THERAPY, extracted from a web site in Canada,  where there
are a lot of "alternative" therapies discussed. Please I do not want to
provoke more confusion as I know that you may feel. Please forgive my bad
English, I'm mailing from Spain and I'm sorry for the delay in the answer,
Just have read your message.

In this sites are "discussions" about the treatment of aminoplastin, among
others as well I'm affraid. <>  . 

    Wish you the best.




This is the information about  antineoplastons.



Many individuals with cancer may wish to investigate unconventional or
unproven therapies. This information, cited from the medical literature and
other sources, is intended to help cancer patients and their families in
their objective evaluation of unconventional therapies.



"After careful study of the literature and other information available to
it, the American Cancer Society does not have evidence that treatment with
antineoplastons results in objective benefit in the treatment of cancer in
human beings. Lacking such evidence, the American Cancer Society would
strongly urge individuals afflicted with cancer not to participate in
treatment with antineoplastons." (CA)


Description / Source / Component

Antineoplastons have been described by Burzynski as "a substance produced by
the living organism that protects it against development of neoplastic
growth by a non-immunological process which does not significantly inhibit
the growth of normal tissues." (CA)

Antineoplastons are "peptides that control cancer growth in the human body."

"Antineoplastons can be extracted from blood serum and urine, and
manufactured synthetically." (Burton Goldberg Group)

"Antineoplaston AS2-1 is a mixture of sodium salts of phenylacetic acid
(PAA) and phenylacetylglutamine (PAG) in the ratio 4:1." It is administered
by injection or orally. Antineoplaston A-10
(3-N-phenylacetylaminopiperidine-2,6 dione) is the active component present
in the urinary antineoplastons. (Green)



Stanislaw R. Burzynski, M.D. and his associates have been working on
antineoplastons as a treatment for cancer since 1967. He works from the
Burzynski Research Institute, Houston, Texas; was educated in Poland and is
licensed to practice in Texas. (CA)


Proponent Claims / Beliefs (unverified)

Burzynski claims that antineoplastons are able to reprogram cancer cells to
restore errors in cellular differentiation to normal. (Burton Goldberg

"Antineoplaston A-10 is an agent derived from human urine which is
remarkable for its antineoplastic activity and lack of toxicity." (Hendry)

These substances are claimed by Burzynski to act as "reverse oncogenes" and
transform malignant tissue into normal tissue. Described as a series of 199
polypeptides derived from urine, it is theorized that a deficiency of this
material in the body predisposes to cancer, while treatment with these drugs
reverses cancer. (Wilson)

In 1977 Burzynski described treatment of 21 advanced cancer patients with
cancer of the breast, bladder, colon, leukemia and other sites - some degree
of clinical improvement was noted in 86 percent of the patients with no
evidence of significant toxicity and minimal side effects. (CA) (Burzynski)


Refutation / Evaluation

"It is not clear from Dr. Burzynski's work what response rate he is actually
claiming. Of the 11 BC Cancer Agency (BCCA) patients known to have been
treated with antineoplastons, 9 have died with no evidence of therapeutic
effect. One remains alive and well after having received treatment at BCCA
which we fully expected to be curative. The remaining patient, who Dr.
Burzynski referred to in Vancouver as his "best case", also received
radiation therapy to all known sites of disease. While the response to
radiation was better than expected, such responses have been seen before and
cannot be fairly attributed to antineoplastons." (Silver 1986)

"Hours after his appearance on the television program 'CBS This Morning',
federal agents raided the Houston office of Dr. Stanislaw Burzynski who has
distributed a controversial cancer drug (Antineoplastons)." (Lum)

The Ontario government sent two Toronto specialists to Burzynski's clinic -
of 20 cases reviewed, no evidence was found that any had benefited from
treatment. Of four patients Burzynski claimed had achieved complete
remissions, three had died of recurrences, the fourth had undergone surgery
for bladder cancer which was believed to be curative. (Dunlop) (Blackstein)

A 38-year-old woman received antineoplaston treatment for her recurrent
rectal cancer involving the lower pelvis at the Burzynski clinic for nearly
a year. During that period, her tumor progressed. "The patient succumbed to
her disease some 6 months later." (Wanebo)

"Five fractions were produced from human urine by Burzynski, A-1, A-2, A-3,
A-4, and A-5. Burzynski does not offer an explanation for the basis on which
he chooses any one specific fraction for treatment of a patient, or why he
has never reported using fractions A-1 or A-4 to treat patients." (Green)

"The so-called five urinary antineoplastons (A-1 to A-5) have not been shown
to be chemically, biologically, or pharmacologically distinct from each
other, and none has been proven to have antineoplastic activity against
experimental cancer." (Green)

Burzynski "offers no explanation of how or where this insoluble substance
[antineoplaston A-10] is made or how it gets from the blood, through the
kidneys, and into the urine. Being insoluble, A-10 is obviously not suitable
for intravenous administration." (Green)

"Burzynski did not follow the accepted scientific method of testing his
products on animals - he claims that extracts from human urine worked only
in humans and that animal testing would be pointless." (Dunlop)

Careful surveillance of the medical literature for the period since 1977 has
revealed no additional reports of clinical trials to date. (CA)

In December 1985 Wayne Ingham, aged 37, of Port Alberni, B.C., died in a
Vancouver hospital following treatment with Burzynski's antineoplastons.
After returning from the clinic with a month's supply of medicine the
Inghams were optimistic the treatments had helped. Following Ingham's death,
his parents said they had a renewed respect for Canadian medical treatment
and ethics. (Sun)

This story has similarities to that of Dr. Burton in the Bahamas. A
biological substance is purported to have dramatic anti-cancer activity.
However, the purification of the compound is complex and has not been
reproduced, there are no firm supporting clinical reports and the agent has
not been made available for impartial evaluation. (Silver 1981)

"Although there is no proof that this and countless other biological
preparations are effective, the burden of proof remains on Dr. Burzynski to
supply more convincing evidence." (Silver 1981)





Toxicity / Risks

". . . two Ontario patients developed septicemia after returning from Texas
and one of them died of septicemia" (Dunlop)

"Some patients have experienced stomach gas, skin rashes, increased blood
pressure, chills, fever and unpleasant body odours." (Ontario)



"Initial consultation is $125. Treatment is given on an outpatient basis at
a cost of approximately $135 to $685 U.S. per day. Diagnostic tests are not
included." (Fink) (Ontario)

In 1982, Dr. Burzynski charged $180 a day for treatments lasting from six
weeks to a year, plus other charges that brought the cost of treatment to
about $4000 a month. Travel costs are not included. A deposit of $5000 is
required. (CA) An Ontario patient, Stephanie Kusan, aged 20 was
unsuccessfully treated by Dr. Burzynski. Cost to the patient was $75,000.



1.	Blackstein ME, Bervgsagel DE. Report to the Ministry of Health,
Province of Ontario based on a preliminary review of Dr. Burzynski's
publications, a site visit on 15 November 1982, and a follow-up review of
some patients treated by Dr. Burzynski. 

2.	Burton Goldberg Group, compiler. Alternative medicine: the
definitive guide. Puyallup, Washington: Future Medicine Publishing, Inc.,

3.	Burzynski S, et al. Antineoplaston A in cancer therapy (I). Physiol
Chem Phys 1977;9:485-500. 

4.	CA (Anonymous). Unproven methods of cancer management:
antineoplastons. CA: a Cancer Journal for Clinicians 1983;33(1):57-59. 

5.	Dunlop M. Understanding cancer: an invaluable book for cancer
patients and their families. Toronto: Irwin, 1985:99-101. 

6.	Fink JM. Third opinion: an international directory to alternative
therapy centers for the treatment and prevention of cancer and other
degenerative diseases. 2nd ed. Garden City Park, New York: Avery Publishing
Group Inc., 1988:36-39. 

7.	Green S. 'Antineoplastons': an unproved cancer therapy. JAMA 1992
Jun 3;267(21):2924-2928. 

8.	Hendry LB, Muldoon TG. Actions of an endogenous antitumorigenic
agent on mammary tumor development and modeling analysis of its capacity for
interacting with DNA. Journal of Steroid Biochemistry 1988;30(1-6):325-328. 

9.	Lum L. Cancer doctor's office raided after TV show. Houston
Chronicle 1995 Mar 28. 

10.	Ontario Breast Cancer Information Exchange Project. Guide to
unconventional cancer therapies. 1sted. Toronto: Ontario Breast Cancer
Information Exchange Project, 1994:253-256. 

11.	Silver HKB. Memorandum on Antineoplaston A. Vancouver: BC Cancer
Agency, 1981. (BCCACancer Information Centre search file 983) 

12.	Silver HKB. Memorandum on Burzynski. Vancouver: BC Cancer Agency,
1986. (BCCA Cancer Information Centre search file 983) 

13.	The Sun. Cancer victim dies despite treatment at radical clinic.
1985 Dec 18:A3. 

14.	Wanebo HJ. Antineoplastons: the controversy continues [letter;
comment]. JAMA 1993 Jan 27;269(4):476. 

15.	Wilson BR (M.D.). Cancer quackery primer. Dallas, Oregon: The
author, 1985.

Copyright © 1996-98 BC Cancer Agency. All Rights Reserved.

----- Original Message ----- 
       From: dasd 
       To: <>  
       Sent: Sunday, October 24, 1999 3:18 PM
       Subject: [MOL] Antineoplastin Therapy
To Whom it may Concern,
       I have been attempting to access any and/or all data regarding the
efficacy of Anitneoplastin Therapy on Pediatric Cancer cases. I
       continually run across one MOL thread referring to a Dr. Stanislau
Burzynski MD, who I know from first hand knowledge, works with
       this therapy. I you have further current information regarding this
therapy, could you please forward this to my attention. 
       I must insist that if you reply; your reply should only contain the
information I am requesting. I DO NOT want to hear from some
       paranoid doctor spouting concern over so-called 'unproven'
treatments/ Alternative medicine. All the conventional methods have been
       exhausted and proven completely worthless, whereas I have met people
who after having had 'Antineoplastin Therapy' are completely
       cancer free. Enough agony, pain & expense has been incurred. PLEASE
respond with the information I require. 
       Thank you!  
Francisco José Millán Benayas        
Tlf: 34-913 86 38 38  Fax: 34-913 73 26 46

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