RE: [MOL] Don't miss reading this one, incl. lung [00521] Medicine On Line

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RE: [MOL] Don't miss reading this one, incl. lung

Hi Lillian,  I have another question.  I saw a commercial last weekend about
some drug (I've forgotten the name of it) that was supposed to stimulate the
production of red blood cells.  The purpose of that being to increase energy
in those people taking chemo.  Have you heard or seen anything about this?


> ----------
> From: 	Lillian[]
> Reply To:
> Sent: 	Thursday, October 14, 1999 4:36 PM
> To: 	mol
> Subject: 	[MOL] Don't miss reading this one, incl. lung
> Importance: 	High
> Study Demonstrates ImmTher Stimulates Immune Response
>   _____  
>   _____  
> CHICAGO -- October 14, 1999 -- Endorex Corporation yesterday reported that
> its bone cancer drug candidate, ImmTherŪ, stimulates human monocytes to
> broad tumoricidal activity against a variety of human cancer cells. These
> findings were published in the latest edition of the oncology medical
> journal, Cancer Immunology and Immunotherapy, in a paper authored by
> Eugenie S. Kleinerman, Professor of Cell Biology, and colleagues, at the
> University of Texas' M.D. Anderson Cancer Center in Houston, Texas.
> ImmTher is currently being evaluated in a randomized phase II trial for
> the treatment of patients with newly diagnosed Ewing's sarcoma. This trial
> is ongoing at two cancer centers: M.D. Anderson Cancer Center and Memorial
> Sloan Kettering Cancer Center in New York. Last year, ImmTher was
> designated as an Orphan Drug by the FDA for the treatment of the primary
> types of bone cancer, Ewing's sarcoma and osteosarcoma. 
> The results of this study titled, "ImmTher, a lipophilic disaccharide
> derivative of muramyl dipeptide, up-regulates specific monocyte cytokine
> genes and activates monocyte-mediated tumoricidal activity," show that
> ImmTher stimulates the production of select body immune responses thought
> to kill tumor cells directly. 
> ImmTher is a novel muramyl dipeptide immunomodulator formulated in
> liposomes, stimulating the body's own natural tumoricidal defenses.
> ImmTher is designed to rid the body of micrometastatic cancer cells that
> have evaded initial chemotherapy or surgery by activating monocytes.
> Monocytes are considered the first line of defense against systemic
> invasion by microbes and cancer cells. Monocytes (or macrophages) interact
> directly with cancer cells by engulfing them or by secreting factors that
> kill them. 
> In phase I testing in patients, ImmTher showed evidence of lung and
> colorectal tumor regression, in addition to inducing elevated levels of
> TNF-(alpha) and neopterin, both cytokine factors involved in tumor killing
> activity. 
> The new findings extend these observations to a clear demonstration that
> high level of cytokines including Interleukin-8, Interleukin-1(alpha),
> Interleukin (beta), TNF(alpha), and Interleukin-12 are up-regulated (or
> stimulated) by ImmTher. 
> According to Dr. Kleinerman, "ImmTher is different from other drugs in
> this class, because it distinctly up-regulates the genes for IL-12. We
> think that one mechanism whereby this drug might exert its action is
> through IL-12 promoted events which include inhibition of angiogenesis and
> stimulation of naive T-cells." 
> Uncovering the mechanism of such drugs may help identify new ways such
> drugs can be used clinically. Explained Dr. Kleinerman, "We were surprised
> that ImmTher had activity not only against human Ewing's sarcoma cells,
> but also against cultured melanoma cells and osteosarcoma cell lines." 
> "These findings demonstrate and underline the potential for using ImmTher
> in this bone cancer and may indicate a broader utility for ImmTher in
> treating other metastatic cancers," stated Michael S. Rosen, President and
> CEO of Endorex. 
> According to the National Cancer Institute, bone tumors account for
> approximately 5 percent of all pediatric cancer. Ewing's sarcoma is the
> second most common primary bone tumor in pediatric patients - accounting
> for 45 percent of bone cancers in U.S. caucasian children, but is rare in
> non-caucasian populations. Ewing's sarcoma is a cancer that responds to
> initial chemotherapy and surgical intervention, but tumors recur in a
> majority of patients within a two-year period. Once tumors have recurred
> in the lungs and other sites, there are no effective therapies for these
> patients. 
> Warmly, lillian 
> We invite you to take a look at our Album.
>   ( Very informational, good tips, Molers pictures, art work and much
> more....
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