Hi, Olivia: It's the kind of cancer I had, too, and I can't tell from this
article whether it eliminates the tumor or merely stops it from growing,
either. You're not the only one! Love, Kathy
-----Original Message-----
From: owner-mol-cancer@lists.meds.com
[mailto:owner-mol-cancer@lists.meds.com] On Behalf Of olivia j dudley
Sent: Saturday, September 25, 1999 9:34 AM
To: mol-cancer@lists.meds.com
Subject: Re: [MOL] DNA vacicination elicits antitumor
activity in small-cell lung cancer....
>Okay I don't fully understand this.
>Does this mean that the vaccine takes out the tumor or does
it mean it stops
>the tumor from spreading.
>This is one of the cancers that spread very rapidly, this
is what I had.
>Please explain.
>Thanks
---
Olivia
On Fri, 24 Sep 1999 16:44:09 Lillian wrote:
>DNA vaccination against HuD antigen elicits antitumor
activity in a small-cell lung cancer murine model.
>Ohwada-A; Nagaoka-I; Takahashi-F; Tominaga-S; Fukuchi-Y
>Am-J-Respir-Cell-Mol-Biol. 1999 Jul; 21(1): 37-43: There is
a clinically significant correlation between the presence of an antibody
against the paraneoplastic encephalomyelitis antigen HuD and the limitation
of tumor spread in patients with small-cell lung cancer (SCLC). This
suggests that HuD is a possible target molecule for antitumor immunotherapy
against SCLC. We have hypothesized that anti-HuD immunity suppresses in vivo
growth of HuD-expressing tumor cells. In this study, Colon 26, a murine
adenocarcinoma cell line, stably transfected with the HuD gene (Colon 26/HuD
cell) was used as a target cell, and the immunity against HuD was evoked by
intramuscular injection of a HuD-expressing plasmid, a technique of DNA
vaccination previously used in BALB/c mice. Colon 26/HuD cells were injected
subcutaneously and tumor size was calculated as a product of width and
length. Antitumor activity was investigated by using two different lots of
Colon26/HuD cells in two protocols: Pro!
tocol 1, in which either Colon 26/HuD or Colon 2!6 cells
were injected in each side, and Protocol 2, in which Colon 26/HuD cells
alone were injected. The size of Colon 26/HuD tumors obtained from mice
vaccinated with HuD-expressing plasmid was significantly smaller than those
from negative control plasmid-vaccinated mice (86.6 +/- 29.9 versus 195.3
+/- 48.1 mm2, P < 0.05 in Protocol 1; 107.7 +/- 12.8 versus 156.6 +/- 22.8
mm2, P < 0.05 in Protocol 2). Moreover, the de novo DNA synthesis of spleen
cells obtained from HuD-vaccinated mice was significantly enhanced. In
addition, anti-HuD antibody was found in individual sera obtained from
HuD-vaccinated mice. DNA vaccination with mouse HuD antigen suppressed
HuD-expressing tumor growth in a murine SCLC model.
>
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