Oliva: I sent this as I knew you had this type of cancer, along with a few
others who are in the background. This mean's that it stops the tumor from
spreading, halts the growth Please understand that first they work with
mice, if the treatment holds promise then they have two trials 1 and 2 that
will see what is the most tolerated dosage that can be given on humans, then
trials 3 & 4 they are refining, noting side effects; etc. At the level of
3&4 even though the product is not marketed for general usage; one can get
it under a clause called "orphan drug". Since you have a very fast growing
tumor and fairly high in stage you may want to talk to you Doctor about
trials. They have many many promising trials out there for most cancers.
It is becoming more and more the concenseious that cancer is a DNA problem,
that for some reason our immune systems cannot recognize the problem and
attack it properly and that there are toxins that activate the tumor cells.
With this knowledge they are able to start separating the gene or genes
which causes various diseases to include cancer, create a vaccine and
hopefully this at some point will be the answer to the cure of cancer. They
are able to do this for many other diseases, and are discovering the DNA
links for many cancers. I hope I have helped you Ovliva and that this
weekend will prove to be a very nice one for you. Your friend, lillian
----- Original Message -----
From: olivia j dudley <oliviadudley@mailcity.com>
To: <mol-cancer@lists.meds.com>
Sent: Saturday, September 25, 1999 8:34 AM
Subject: Re: [MOL] DNA vacicination elicits antitumor activity in small-cell
lung cancer....
> >Okay I don't fully understand this.
> >Does this mean that the vaccine takes out the tumor or does it mean it
stops
> >the tumor from spreading.
> >This is one of the cancers that spread very rapidly, this is what I had.
> >Please explain.
> >Thanks
> ---
> Olivia
>
>
> On Fri, 24 Sep 1999 16:44:09 Lillian wrote:
> >DNA vaccination against HuD antigen elicits antitumor activity in a
small-cell lung cancer murine model.
> >Ohwada-A; Nagaoka-I; Takahashi-F; Tominaga-S; Fukuchi-Y
> >Am-J-Respir-Cell-Mol-Biol. 1999 Jul; 21(1): 37-43: There is a clinically
significant correlation between the presence of an antibody against the
paraneoplastic encephalomyelitis antigen HuD and the limitation of tumor
spread in patients with small-cell lung cancer (SCLC). This suggests that
HuD is a possible target molecule for antitumor immunotherapy against SCLC.
We have hypothesized that anti-HuD immunity suppresses in vivo growth of
HuD-expressing tumor cells. In this study, Colon 26, a murine adenocarcinoma
cell line, stably transfected with the HuD gene (Colon 26/HuD cell) was used
as a target cell, and the immunity against HuD was evoked by intramuscular
injection of a HuD-expressing plasmid, a technique of DNA vaccination
previously used in BALB/c mice. Colon 26/HuD cells were injected
subcutaneously and tumor size was calculated as a product of width and
length. Antitumor activity was investigated by using two different lots of
Colon26/HuD cells in two protocols: Pro!
> tocol 1, in which either Colon 26/HuD or Colon 2!6 cells were injected in
each side, and Protocol 2, in which Colon 26/HuD cells alone were injected.
The size of Colon 26/HuD tumors obtained from mice vaccinated with
HuD-expressing plasmid was significantly smaller than those from negative
control plasmid-vaccinated mice (86.6 +/- 29.9 versus 195.3 +/- 48.1 mm2, P
< 0.05 in Protocol 1; 107.7 +/- 12.8 versus 156.6 +/- 22.8 mm2, P < 0.05 in
Protocol 2). Moreover, the de novo DNA synthesis of spleen cells obtained
from HuD-vaccinated mice was significantly enhanced. In addition, anti-HuD
antibody was found in individual sera obtained from HuD-vaccinated mice. DNA
vaccination with mouse HuD antigen suppressed HuD-expressing tumor growth in
a murine SCLC model.
> >
>
>
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