Re: [MOL] question on myelofibrosis/Reply [00257] Medicine On Line

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Re: [MOL] question on myelofibrosis/Reply

Hi, Welcome to our wonderful forum.  I have included everything you will want to know about this cancer.  Keep in mind that it is important to always maintain hope, that there is on one being that know's the answers to our lives.  Good luck and if I may be of further help, just e-mail us.  Your friend, lillian 


Primary myelofibrosis

Alternative names:
myelofibrosis; idiopathic myelofibrosis; myeloid metaplasia; agnogenic myeloid metaplasia

A disorder of the bone marrow in which the marrow is replaced by fibrous (scar) tissue.

Causes, incidence, and risk factors:
In primary myelofibrosis, blood formation occurs in sites other than the bone marrow, such as the liver and spleen, causing enlargement of these organs. The cause is unknown. The disorder usually develops slowly in persons over 50 years old. It leads to progressive bone marrow failure with severe anemia. Low platelet count leads to easy bleeding, and spleen enlargement continues. The disease is progressive without a cure. The incidence is 2 out of 100,000 people.

There is no known prevention.

Signs and tests:
Physical examination shows an enlarged spleen. Later in the disease it may also show an enlarged liver.
This disease may also alter the results of the following tests:
There is no specific treatment for primary myelofibrosis. Blood transfusions are given to correct anemia. Recombinant erythropoietin or androgens may stimulate red blood cell production and may be beneficial. Splenectomy (removal of the spleen) may be indicated where splenic enlargement causes symptoms related to its size. Radiation and chemotherapy may also be used.

Expectations (prognosis):
The median survival of people with primary myelofibrosis is about 5 years. However, many people survive for decades. End-stage disease is a wasting illness with debility.

Calling your health care provider:
Call for an appointment with your health care provider if symptoms of this disorder develop. Uncontrolled bleeding, shortness of breath, jaundice, and progressive confusion are symptoms that indicate a need for urgent or emergency care.

----- Original Message -----
From: g5923747
Sent: Tuesday, July 06, 1999 3:06 PM
Subject: [MOL] question on myelofibrosis

My grandma's brother has myelofibrosis and she was wondering if it can affect the colon and appendix as well. Is there anything else it can affect besides the spleen and liver? Thank you.   

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