Hi, Welcome to our wonderful forum. I have included everything you will
want to know about this cancer. Keep in mind that it is important to
always maintain hope, that there is on one being that know's the answers to our
lives. Good luck and if I may be of further help, just e-mail us.
Your friend, lillian
Alternative names: myelofibrosis; idiopathic
myelofibrosis; myeloid metaplasia; agnogenic myeloid metaplasia
Definition: A disorder of the bone marrow in which the
marrow is replaced by fibrous (scar) tissue.
Causes, incidence, and risk
factors: In primary myelofibrosis, blood formation occurs in
sites other than the bone marrow, such as the liver and spleen, causing
enlargement of these organs. The cause is unknown. The disorder usually develops
slowly in persons over 50 years old. It leads to progressive bone marrow failure
with severe anemia. Low platelet count leads to easy bleeding, and spleen enlargement continues. The disease is progressive without
a cure. The incidence is 2 out of 100,000 people.
Treatment: There is no specific treatment for primary myelofibrosis. Blood transfusions
are given to correct anemia. Recombinant erythropoietin or androgens may stimulate red blood cell production and may be
beneficial. Splenectomy (removal of the spleen) may be indicated where
splenic enlargement causes symptoms related to its size. Radiation and chemotherapy may also be used.
(prognosis): The median survival of people with primary
myelofibrosis is about 5 years. However, many people survive for decades.
End-stage disease is a wasting illness with debility.