[MOL] Rish of Stomah Cancer [01343] Medicine On Line

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[MOL] Rish of Stomah Cancer

H. Pylori Caga Gene Associated with Increased Risk of Stomach Cancer in Under-40s

WESTPORT, Jun 15 (Reuters Health) - Italian patients younger than 40 years of age have close to a three-fold increased risk of stomach cancer when infected with H. pylori strains that are positive for cagA (cytotoxin-associated gene A). These findings are from a retrospective study published in the June 15th issue of Cancer.

Dr. Massimo Rugge, of the University of Padova, and a multinational group explain that infection with cagA-positive H. pylori strains is associated with intestinal type gastric carcinoma in the general population, adding that gastric cancers are rarely observed in patients aged 40 years and younger.

They examined the medical records of 105 gastric carcinoma patients and 105 age- and gender-matched controls.

Among the cancer patients, the Italian researchers found that 74 had diffuse gastric cancer, and 31 had intestinal gastric cancers.

Dr. Rugge and colleagues report that cancer patients were 2.79 times as likely to have H. pylori infection as controls. Their statistical calculations also showed that carriage of cagA positive bacteria was associated with a relative risk of 2.94 for developing gastric carcinoma.

This "...significant association with cagA positive H. pylori infection suggests that the bacterium has an etiologic role in both diffuse and intestinal-type gastric carcinoma," the group concludes.