[MOL] Engineered Ribonuclease May Be Useful For Targeted Cancer Therapy [00285] Medicine On Line

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[MOL] Engineered Ribonuclease May Be Useful For Targeted Cancer Therapy

Some More HOpe on the way.

WESTPORT, Mar 01 (Reuters Health) - A ribonuclease, genetically
engineered to increase uptake by tumor cells and to block the
cytosolic ribonuclease inhibitor, exhibits greatly enhanced
cytotoxicity, researchers report in the March issue of the
journal Nature Biotechnology.  A multicenter research team
including Dr.  Richard J. Youle of the National Institutes of
Health (NIH) in Bethesda, Maryland, first incorporated cysteine
residues at sites on ribonucleases that are believed to bind to
the cytosolic inhibitor.  This "...produced enzymatically active
conjugates that were resistant to [ribonuclease inhibitor]." They
then further modified these mutant RNases by conjugating them
with transferrin, to target transferrin receptors that are
disproportionately expressed on tumor cells.

God Bless
marty auslander
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