[MOL] Gene Key to Cancer Cells Actions [02885] Medicine On Line


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[MOL] Gene Key to Cancer Cells Actions



Gene Holds Key to Cancer Cells Actions

Researchers have reported findings that suggest malfunctions in a single gene may influence whether nor not cancer cells take hold in the body or are destroyed by the immune system. Researchers at Ohio State University in Columbus say that studies in recurrent tumor cells found that mutated forms of a gene called PML can result in reduced production of major histocompatibility complex (MHC) antigens, which are known to aid in the discrimination between healthy cells and cancer cells by the immune system. Authors further note that experiments conducted with human leukemia cells which lacked MHC and had malfunctioning PML genes showed that treatment with a chemical that allowed PML to function again resulted in renewed production of MHC. The findings are in the journal Nature (1998;396:373-376).