Re: [MOL] thalidomide [00106] Medicine On Line

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Re: [MOL] thalidomide

Title: thalidomide
Thanks lillian - I am way behind in my mail and hadn't seen this.  I will keep you posted on my progress and especially if they decide to do some other treatment with me so my my experience may help others.  I haven't seen many messages of individiuals with "brain" tumors.  Are there not many individuals with brain tumors in this forum?  Thanks for your help. Your friend, jo
-----Original Message-----
From: lillian jennings <>
To: <>
Cc: <>
Date: Saturday, January 23, 1999 7:49 PM
Subject: Re: [MOL] thalidomide

I am not sure if you saw this message; so I am sending it to you in hopes that it helps.  Your friend, lillian
In March 1996, the FDA unveiled a plan to speed new oncology drugs to
market. Thalidomide, AngiostatinTM protein, EndostatinTM protein, and
2-Methoxyestradiol could be candidates for such "fast-track" approval by
the U.S. Food & Drug Administration, although there is no certainty as to
when such approvals could be attained.

Thalidomide, as an antiangiogenic, is being tested in Phase II clinical
trials in Kaposi's sarcoma and in prostate, breast and brain cancers. The
trials are in collaboration with the National Cancer Institute, with
studies underway at the National Institutes of Health in Bethesda, MD, the
Lombardi Cancer Center at Georgetown University in Washington, DC, the
Dana-Farber Cancer Institute at Harvard in Boston, MA, the M.D. Anderson
Hospital in Houston, TX, and the University of Chicago.

The testing is in Phase II of a three-phase clinical cycle. Preliminary
results from this phase indicate biological activity in the glioblastoma
(brain), Kaposi's sarcoma and prostate cancer studies.

Thalidomide is also being tested in Phase II trials in macular degeneration
at the Scheie Eye Institute in Philadelphia, PA and with the Retinal
Associates of Cleveland.

In March 1996, the FDA unveiled a plan to speed new oncology drugs to
market. Thalidomide
-----Original Message-----
From: Jo Siller <>
To: <>
Date: Saturday, January 23, 1999 7:40 PM
Subject: Re: [MOL] thalidomide

I have recently been diagnosed with an astrocytoma brain tumor and have had radiation to treat it.  The doctors said that there is no evidence that giving me Thalidomide would do any good to help eliminate the tumor so they decided not to continue on with any more radiation, chemotherapy or any other treatments.  They will just follow the tumor with MRI's.  My question is: what information do you have regarding Thalidomide and brain tumors?
-----Original Message-----
From: Debi Estabrook <>
To: '' <>
Date: Wednesday, January 20, 1999 7:00 AM
Subject: [MOL] thalidomide

I have a friend who's 42 year old brother has colon cancer that has spread to his liver (and I believe other areas).  She read about Thalidomide and what it has done for people with brain tumors and is interested in seeing if this drug has been used to treat colon cancer.   Can you help me find a clinical trial that he might participate in?