[MOL] U.S. Scientists Find Chemicals For Cancer Therapy [00292] Medicine On Line


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[MOL] U.S. Scientists Find Chemicals For Cancer Therapy



Hi All,

Season's Greetings and Happy New Year to All !

I am back. My mother is still struggling with the cancer metastassized in the 
liver. The 5fu with lucoverin had failed on her. Now she's been treated with 
Kamptosar. She's also taking some Floressence(the essiac tea combination).
Can you folks suggest anything else that she can take to help with the severe
side-effects(Diarrhoea, Vomiting, etc) and generating healthy cells in her body 
? Any other therapy that can prolong her life ??? Just to remind you, she has
colon cancer with liver metastassis(Stage IV), undergone a colostomy. 

Here is some good news to share ... ( This technology will take time in reaching 
other countries around the world but is a light of hope for those in US )

FYI, I am not on the mol-cancer@lists.meds.com alias for the time being but will
be joining it soon with another email account.
In the meanwhile pls, do not forget me and keep in touch by sharing any info.
you feel may be helpful in saving my Mom's life.

Thanks and Good Wishes to All -

-Apala

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Monday January 4 5:11 PM ET  
 
U.S. Scientists Find Chemicals For Cancer Therapy 
 
By Dan Whitcomb 
 
LOS ANGELES (Reuters) - A team of U.S. scientists reported Monday a discovery 
that  
could lead to a cancer treatment more gentle on the human body than 
traditional  
chemotherapy. 
 
In a report to be published Tuesday, the team based at the University of 
California  
at Los Angeles said it discovered a family of chemicals that could allow 
doctors to  
 use ``boron neutron capture therapy'' on cancer patients. 
 
The UCLA scientists said the new cancer therapy would be less harsh on the 
body than  
traditional chemotherapy because it targets only cancer cells and kills them 
with nuclear  
fission instead of chemicals that poison the body. The team's findings were 
published in 
the Journal Proceedings of the National Academy of Sciences. 
 
``It would be selective for cancer cells and therefore the therapy itself 
would be  
much less debilitating for the patient,'' Frederick Hawthorne, a UCLA chemist 
who led the 
 research team, told Reuters in an interview. 
 
``If (the therapy) lives up to expectations, it will be much more comfortable 
for the  
patient than chemotherapy or other types of radiation therapy,'' he said. 
 
Hawthorne said it was too early to tell if the boron therapy, which faces 
several  
years of clinical trials before it could be made available to the public, 
would be  
 more effective than current cancer treatments. 
 
The concept of using boron-based compounds to fight cancer has been around 
since  
the 1930s, when scientists discovered that those compounds accumulate in 
cancerous tumors. 
 
But the newly discovered family of chemicals is the most effective so far at  
 delivering the boron into the nucleus of the cancer cells, 
Hawthorne said. Once there, the boron is ''activated'' by exposing the cancer 
 cells to a beam of neutrons, producing nuclear fission 
that destroys the cells' DNA. 
 
``Boron can be considered something like a land mine, because it's just 
sitting  
 there until something comes along and steps on it,'' 
Hawthorne said. ``In this case, that something is the neutron. And when it 
goes off, 
 it destroys whatever happens to be around it.'' 
 
That capability could make it more attractive than chemotherapy, which damages  
 healthy cells as it kills cancer cells and often leaves the patient ill in 
the process. 
 
``What all these methods would love to do is cure cancer without disturbing 
normal  
tissue nearby,'' Hawthorne said. ''This particular method would allow one to 
do just that.'' 
 
Currently, clinical trials are proceeding using boron therapy, but with less 
efficient  
chemicals, Hawthorne said. 
 
``The difference is that our stuff goes to the nucleus of the cancer cell,'' 
he said.  
``The whole idea is to destroy the cancer cell's 
DNA. No one has had the chemical compounds that we discovered at UCLA.'' 
 
Hawthorne, 70, a pioneer in the field of boron chemistry, said that if the 
therapy is  
proven to be effective, it potentially could be used to fight a variety of 
cancers. 

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