[MOL] Acetaminophen May Have Potential as Antioxidan [13476] Medicine On Line


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[MOL] Acetaminophen May Have Potential as Antioxidan



Good EVening My Friends,

Thought you would like to know.



Acetaminophen May Have Potential as Antioxidant



HOUSTON--(BUSINESS WIRE)--July 29, 1998--



Research Shows Pain Reliever May Help Protect Against Changes



Leading to Hardening of Arteries



New research suggests that acetaminophen, a widely used pain reliever,

may help protect the blood from changes leading to hardening of the

arteries -- a condition that contributes to hundreds of thousands of

deaths per year from stroke, heart attack, and other forms of

cardiovascular disease.



Addison A. Taylor, MD, PhD, Professor of Medicine and Pharmacology,

Baylor College of Medicine, Center for Experimental Therapeutics,

Houston, presented the findings at today's session of the Thirteenth

IUPHAR Congress of Pharmacology in Munich.



Dr. Taylor reported findings in 12 healthy human volunteers suggesting

an association between the use of acetaminophen at recommended doses

and a significant inhibition of the oxidation of certain low-density

lipoproteins, which carry the form of cholesterol commonly described as

"bad cholesterol."



"The oxidation of cholesterol-containing, low-density lipoproteins is

one of the main processes involved in the formation of arterial plaque,

which accumulates in the walls of blood vessels and contributes to

hardening of the arteries, or atherosclerotic disease," explained Dr.

Taylor.



"While further study is required to make any definitive association

between acetaminophen and a protective effect in patients at risk of

cardiovascular disease, what we observed is promising and may suggest a

potential clinical role for acetaminophen as an antioxidant," said Dr.

Taylor. Antioxidants are substances that counteract the damaging

effects of oxygen in tissues. Vitamin E, which is among the more

commonly known antioxidant agents, is believed to provide protection

against certain forms of cancer, cardiovascular disease, and other

conditions.



The study conducted by Dr. Taylor and his associates was a randomized,

blinded, placebo-controlled trial involving the administration of eight

doses of acetaminophen (1,000 mg doses every six hours). Plasma samples

from patients who received acetaminophen were then compared with those

from patients who received no treatment.



Dr. Taylor noted that the results of this study support those reported

by other investigators.



"Although our research was the first to examine the effects of

acetaminophen on low-density lipoproteins in humans, other

investigators have reported similar findings in laboratory settings,"

said Dr. Taylor. "The next step will be to confirm these findings in

larger studies, both in animals and in humans."



Atherosclerosis is a major contributor to coronary heart disease and

stroke. Coronary heart disease is the country's number one killer of

both men and women, while stroke claims an estimated 150,000 U.S. lives

each year.



Baylor College of Medicine is a leading research and teaching

institution. The college's Center for Experimental Therapeutics

examines the effects of drugs on man with special emphasis on

cardiovascular disease.



CONTACT:



Baylor College of Medicine, Houston



------------------------------

HOPe this information Benefits those that are using or being

administered with this medicine.



God Bless

marty auslander
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