[MOL] Hycamtin encouraging treatment for Multiple Myeloma [12768] Medicine On Line


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[MOL] Hycamtin encouraging treatment for Multiple Myeloma



Another Positive message this morning about this therapy for multiple
diseases. Hope it brings a ray of sunshine to your plans for wellness.

God Bless
marty auslander


HYCAMTIN SHOWS ACTIVITY IN MULTIPLE MYELOMA
Encouraging Results Seen in Treatment of Bone Marrow Cancer

PHILADELPHIA, PA, February 20, 1998 - According to a new study published
this
month in the Journal of Clinical Oncology, Hycamtin  (topotecan
hydrochloride
for injection, SmithKline Beecham) may offer a new option for the
treatment
of multiple myeloma (a type of bone marrow cancer).  In this study,
patients
with relapsed and resistant myeloma who received Hycamtin as a
single-agent
therapy demonstrated a 16 percent response rate and a median survival
time of
28 months.  These results are comparable to those seen with other
effective
drugs used as single-agent therapies in refractory and relapsed disease.
Hycamtin is available for the treatment of recurrent, metastatic ovarian
cancer and is not currently indicated for use in the treatment of
multiple
myeloma.

"There is a great need to identify new agents that can be used to treat
patients with relapsed and refractory multiple myeloma, since
second-line
treatment is very challenging and the prognosis is poor for most
patients.
The activity we observed with Hycamtin as a single-agent therapy is
encouraging, and we plan to study this drug in combination with other
agents
in the treatment of multiple myeloma patients," said Eric H. Kraut,
M.D.,
professor of medicine, division of hematology/oncology, Ohio State
University, and lead study investigator.
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