[MOL] NEW PERSPECTIVES ON DIET AND CANCER [12383] Medicine On Line


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[MOL] NEW PERSPECTIVES ON DIET AND CANCER



NEW PERSPECTIVES ON DIET AND CANCER 
Interview with American Cancer Society's Daniel Nixon, M.D. 

When not at the Pentagon or on active duty in the Naval Reserves, Daniel W. Nixon, M.D. serves as vice president of professional education for the American Cancer Society in Atlanta. Prior to his current position, Dr. Nixon spent the majority of his career in medical oncology at Emory University School of Medicine, with more than 15 years of specialized research in diet-related manuscripts in books and journals. He currently serves on several nutrition committees for the National Cancer Institute and is co-editor in chief of the internationally recognized journal, Cancer Prevention. 

HOW DO THE NEW DIETARY GUIDELINES RECENTLY ISSUED BY THE AMERICAN CANCER SOCIETY DIFFER FROM THE PREVIOUS VERSION? 

The American Cancer Society (ACS) first published nutritional guidelines in 1982, and they have evolved over time. Today, ACS guidelines are not materially different from the dietary recommendations of the National Cancer Institute and the American Heart Association. All three organizations stress the importance of eating a low-fat, high-fiber diet and plenty of fruits and vegetables. 

The new ACS guidelines emphasize eating a variety of foods. It seemed that some people were eating only cruciferous vegetables to the exclusion of other foods. Thus, we stress the need to eat a varied diet, rather than any one particular food or group of foods. 

Our new guidelines also emphasize the need to limit or control obesity, not only through decreased caloric intake, but through exercise as well. The leading ACS recommendation is to avoid being overweight. 

WHY AREN'T THERE ANY QUANTITATIVE RECOMMENDATIONS IN THE NEW GUIDELINES? 

We feel the data are not solid enough to quantify now many grams of fiber it takes to prevent colon cancer, for example, or how few grams of fat will reduce risk of breast cancer. We give a general range for dietary fat, which is 30 percent of calories or less. 

IS IT THE PERCENT OF CALORIES FROM FAT OR THE TOTAL NUMBER OF CALORIES IN THE DIET THAT INCREASES CANCER RISK? 

Fat intake and total calories are both important. It's clear from animal studies that both fat itself and calories, whether from fat or from other foods, play a role, probably not as cancer initiators but as cancer promoters. 

WHAT IS THE CURRENT EVIDENCE ON POLYUNSATURATED FAT AND CANCER? 

The polyunsaturate story is still very cloudy as far as cancer is concerned. At this point, we would advise people to watch their total fat intake rather than worry about the type of fat they're consuming. 

WHY DOES BEING OVERWEIGHT INCREASE THE RISK OF CANCER? 

There are two phenomena going on. When people consume excess calories, it stimulates the metabolic overdrive into making cells divide faster. This increases the risk that something can go awry, resulting in cancerous cells. Then too, fat people have more cells, so there is an increased statistical chance that some of those cells might become cancerous. 

WHAT ROLE DO ANTIOXIDANTS PLAY IN PREVENTING CANCER? 

Vitamins A, C and E are known to have certain antioxidant properties. It's believed that these antioxidants work by stopping damage to the DNA; or if the DNA is already damaged, they help in its repair. 

But there are also other properties in vitamins that work to prevent cancer. For example, vitamin A retinoids seem to be able to take cells that are on the way to becoming malignant and help restore them to normal activity. This has been shown in studies of pre-malignant regions of the head and neck; doses of synthetic retinoids have been able to reverse that condition. So there's more than one possible good effect of vitamins. 

ACS GUIDELINES ON DIET, NUTRITION AND CANCER 

•Maintain a desirable body weight. •Eat a varied diet. •Include a variety of both vegetables and fruits in the daily diet. •Eat more high-fiber foods, such as whole-grained cereals, legumes, vegetables and fruits. •Cut down on total fat intake. •Limit consumption of alcoholic beverages, if you drink at all. •Limit consumption of salt-cured, smoked and nitrite-preserved foods. 

DO SO-CALLED "DESIGNER FOODS" HOLD GREAT POTENTIAL IN CANCER PREVENTION? 

We're just beginning to understand what characteristics to design into foods. Foods, including fruits and vegetables, have many more useful substances in them besides vitamins. In designing anti-cancer foods like the 'super carrot,' we don't want to inadvertently eliminate other essential components at the same time. For example, there are potentially beneficial chemicals in foods that are not nutrients as we understand them. The compound beta-glycyrrhetinic acid gives licorice its distinctive taste, but is also a potent chemo-preventive agent in laboratory animals. It's not a nutrient in the standard sense. 

That's also why ACS's nutritional guidelines don't include the recommendation to take vitamin supplements. It's not just the benefits of certain vitamins in food, but rather the combination of vitamins and these compounds that can help reduce cancer risk. 

ARE PEOPLE WHO CONSUME MORE FRUITS AND VEGETABLES AT INCREASED CANCER RISK FROM PESTICIDE RESIDUES? 

The consensus of our work study group on diet, nutrition and cancer was that the benefits of eating fruits and vegetables far outweigh any potential risk from pesticide residues. 

Most pesticide residues are reduced through food processing and by washing fruits and vegetables. Nonetheless, the committee will continue to monitor data in this area. 

SHOULD PARENTS BE CONCERNED ABOUT THE PESTICIDE RISKS TO INFANTS AND CHILDREN? 

The ACS dietary guidelines apply to children over the age of two years. But in terms of nutritional guidelines for young children, I think parents should be more concerned about the overall eating patterns they're setting for their lifetimes, rather than focusing on any specific food risks like pesticide residues. 

WHAT KINDS OF CANCERS AFFECT CHILDREN? ARE THEY RELATED TO DIET IN ANY WAY? 

The common types of pediatric cancers are bone tumors, leukemias, brain tumors and lymphpomas such as Hodgkin's lymphoma. But in the childhood group, I'm not aware of any increase in tumors that are thought to be linked to diet. That's why it's important that good eating habits are set for a lifetime, because the diet-related tumors are those that affect adults - breast cancer, colon cancer and prostate cancer, for example. 

WHAT ABOUT THE NATURAL CARCINOGENS THAT ARE PRESENT IN FOOD? 

One thing that has confused the public is the difference between a mutagen and a carcinogen; they're not the same thing. Just because something is a mutagen, which means it can change bacteria on the Ames test, does not mean it will cause cancer in humans. 

The fact that food mutagens are present is not proof that food carcinogens are present. Nonetheless, the liver has developed a sophisticated detoxification system to ward off these compounds fairly efficiently. 

WHAT KINDS OF DIETARY RESEARCH IS ACS CURRENTLY FUNDING? 

We've just completed field-testing the new ACS dietary guidelines with a healthy population to determine if they accomplished what we intended (see above). With the success of that project, we're now moving into the next phase of our research plan, which aims to develop cancer- specific nutritional guidelines. 

We're funding two studies: one limits dietary fat intake in patients with breast cancer and the other prescribes a high-fiber cereal for persons with abnormal polyps of the colon. 

KEEPING IN SHAPE 

How likely are you to lose weight on a Mediterranean cruise? Not very, unless the only meals available are prepared according to the new American Cancer Society dietary guidelines. To put those guidelines to the test, ACS tried them out on an entire U.S. Navy crew that was shipped to the Mediterranean for a six-month deployment in 1990. Before they went to sea, the ship's cooks were instructed on how to prepare menus designed to conform to the new guidelines and crew members were educated about them as well as the importance of exercise. 

Before and after the mission, the 350 crew members on the USS Scott underwent tests to determine their overall health. For comparison, similar data were collected from crew members on a separate ship on which standard Navy menus were served. Preliminary results showed immediate health benefits for the USS Scott crew. 

USS Scott crew members lost an average of 10 pounds and took nearly two inches off their waists. Crew members on the other ship gained an average of seven pounds and their waist sizes grew one to two inches. 

In addition, of those USS Scott members who weighed 200 pounds or more at the start of the mission, 74 percent lost weight. Only 26 percent of the similar group lost weight on the other ship, and 74 percent of the 200 pound-plus group gained weight. 

For meals, sailors were served foods like oven-roasted lean meats and baked potatoes in place of fried steaks and mashed potatoes with gravy. Low-fat frozen yogurt and low-fat cookies were offered in place of other higher-fat desserts. 

The USS Scott commander was concerned that a change of diet not adversely affect the crew's morale, so he insisted that the ship's commissary continue to sell candies and other snacks. It appears those occasional foods did not interfere with the overall benefits of the ACS diet. 

As it turns out, many sailors on the USS Scott preferred the new diet and 44 percent said they would maintain similar eating habits on land. 

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