Re: [MOL] cyfra21-1 or cytokeratins [11233] Medicine On Line


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Re: [MOL] cyfra21-1 or cytokeratins



I am a cancering survivor of Stage IIb lung cancer; adenocarcinoma with one lymph node involvement.  I have also heard about there being blood tests that can detect the potential of recurrence, but I don't have any information on it..  I went to a meeting at the herb society and there was a doctor of Internal Medicine who spoke there and told me afterwards that he could tell from blood tests if recurrence was indicated, but when I tried to make an appointment with him.. his receptionist and I are not seeing eye to eye and so after 3 phone calls.. still nothing..  She is insisting that I must change to him as my primary care physician and my insurance company says I don't have to.. so  nothing to report there..
I have had 2 PET scans done and I truly believe in them..  They are not 100% accurate but in the 90+ Percentile for detecting tumors at .5cm.  I would gladly trade in CT scans for the PET only...  I have much more faith in them.
My oncologist did a Bone Marrow Micrometastases test as well, which is used as an indicator/predictor of recurrence.  The following is the information on it: 
 
QuickScan Reviews in Cancer Management; 1996; February

Detection of Occult Bone Marrow Micrometastases in Patients With Operable Lung Carcinoma.  Cote RJ, Beattie EJ, et al:
ANN SURG 1995; 222 (October): 415-425
 
Objective: To assess bone marrow micrometastases (BMM) as a predictor of systemic disease in patients with primary operable non-small-cell carcinoma of the lung.  Design/Participants: Prospective analysis of 43 patients with stage I (n= 1 5), 11 (n=2), or III (n=26) lung cancer undergoing potentially curative resection.  Interventions: Bone marrow specimens were collected from a rib fragment. lmmunohistochemical staining was performed with two monoclonal antibodies that recognize epithelial tumor cell markers.  Results: Of the 43 patients, 17 (40%) had bone marrow micrometastases detected (stage 1, 33%; stage 11, 0%; and stage III, 46%).  With a median follow-up of 13.6 months, patients with BMM had a significantly higher risk of tumor recurrence (77% [13 of 17 patients] vs 23% [6 of 26]).  Patients with BMM had significantly earlier disease recurrence than those without BMM (median, 7.3 months vs 35.1 months) regardless of primary tumor stage.  By multivariate analysis, the presence of BMM was an independent predictor of disease.  Conclusions: The presence of bone marrow micrometastases predicts a significantly higher risk of metastatic disease in lung cancer patients.  Reviewer's Comments: This is a small experience, but it corroborates similar findings in breast and colorectal cancer patients.  Larger confirmatory studies (which should also evaluate the practicality and cost of this test) are needed before this method can be used clinically. (Reviewer-John H. Donohue, MD).
Additional Keywords: bone cancer chest lung lungs marrow metastases
Reprints: Department of Pathology, USC School of Medicine; 2011 Zonal Ave, HMR 204; Los Angeles, CA 90033 (Richard J. Cote, MD).
 
I hope that I have helped somewhat.. If you learn anymore about the blood test.. please email it to me at Blessu@worldnet.att.net
Thank you and God Bless you.. Carla
 
-----Original Message-----
From: Joseph Patella <jtpat1@monmouth.com>
To: mol-cancer@lists.meds.com <mol-cancer@lists.meds.com>
Date: Sunday, July 05, 1998 11:55 PM
Subject: [MOL] cyfra21-1 or cytokeratins

>I have heard that a blood test referred to as cyfra21-1 could detect
>recurring lung cancers.  I have had state 1 non small cell lung cancer,
>had a lobectomy performed and have been cancer free almost three years.
>I am interested in learning about any blood tests or other tests such as
>PET tests that can detect recurring tumors.  If anyone has information
>about these or other tests, p;ease e-mail me at jtpat1@monmouth.com.
>
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