Re: [MOL] Sandra [05952] Medicine On Line


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Re: [MOL] Sandra




-----Original Message-----
From: firefly <firefly@islc.net>
To: MOL <mol-cancer@lists.meds.com>
Date: Monday, May 11, 1998 1:52 PM
Subject: [MOL] For Informational Purposes!


>Tamoxifen and Raloxifene: Making Sense of the New Breast Cancer Drugs
>
>by Samme Chittum
>
>Just when women thought they knew the ups and downs of tamoxifen, the first
>drug found to prevent breast cancer, another drug, raloxifene, is now front
>page news as well.
>Raloxifene, sold under the brand name "Evista" (made by Eli Lilly and Co.),
>is prescribed to help prevent osteoporosis, a chronic, debilitating
>condition in which bones weaken and deteriorate.
>But now raloxifene is in the spotlight for another reason. Preliminary data
>released by the National Cancer Institute shows raloxifene may also offer
>the same breast cancer preventing protection of tamoxifen -- a 50 percent
>reduced rate of cancer in clinical trials; but without tamoxifen's
>downside -- an increased risk of uterine cancer.
>"The safety profile of Evista is very high compared to tamoxifen," says Dr.
>Maurice Cohen, director of the Women's Health Program at North Shore
>Diabetes and Endocrine Associates in New York.
>What's the difference between the two drugs, and how will you know if
either
>one is right for you? The main distinction is that while tamoxifen has been
>FDA approved as a breast cancer prevention medication, it has potentially
>serious risks. And raloxifene, which has only a few side effects such as
leg
>cramps or possible blood clots in the legs, has only been approved to help
>prevent osteoporosis and lower cholesterol in postmenopausal women. That it
>might also have the added benefit of reducing a woman's risk of breast
>cancer is possible, but not yet certain.
>Nevertheless, some doctors are hopeful about raloxifene's numerous
potential
>benefits.
>"With raloxifene, you're getting a lot of bang for you medical dollar,"
says
>Dr. Steven Goldstein, a gynecologist at New York University Medical Center.
>While this may be true, researchers are still studying the effects that
>raloxifene has on preventing breast cancer. Until those studies are
>complete, the drug remains one that is only prescribed to women at risk for
>osteoporosis.
>That's fine for some women's advocates who want more proof before jumping
on
>the raloxifene bandwagon. "It's far too soon to say that raloxifene
prevents
>breast cancer," says Cindy Pearson of the nonprofit National Women's Health
>Network.
>iVillage and Better Health are trademarks of iVillage, Inc.
>Your friend Lillian

>Tamoxifen and Raloxifene: Making Sense of the New Breast Cancer Drugs
by Samme Chittum
Just when women thought they knew the ups and downs of tamoxifen, the first
drug found to prevent breast cancer, another drug, raloxifene, is now front
page news as well.
Raloxifene, sold under the brand name "Evista" (made by Eli Lilly and Co.),
is prescribed to help prevent osteoporosis, a chronic, debilitating
condition in which bones weaken and deteriorate.
But now raloxifene is in the spotlight for another reason. Preliminary data
released by the National Cancer Institute shows raloxifene may also offer
the same breast cancer preventing protection of tamoxifen -- a 50 percent
reduced rate of cancer in clinical trials; but without tamoxifen's
downside -- an increased risk of uterine cancer.
"The safety profile of Evista is very high compared to tamoxifen," says Dr.
Maurice Cohen, director of the Women's Health Program at North Shore
Diabetes and Endocrine Associates in New York.
What's the difference between the two drugs, and how will you know if either
one is right for you? The main distinction is that while tamoxifen has been
FDA approved as a breast cancer prevention medication, it has potentially
serious risks. And raloxifene, which has only a few side effects such as leg
cramps or possible blood clots in the legs, has only been approved to help
prevent osteoporosis and lower cholesterol in postmenopausal women. That it
might also have the added benefit of reducing a woman's risk of breast
cancer is possible, but not yet certain.
Nevertheless, some doctors are hopeful about raloxifene's numerous potential
benefits.
"With raloxifene, you're getting a lot of bang for you medical dollar," says
Dr. Steven Goldstein, a gynecologist at New York University Medical Center.
While this may be true, researchers are still studying the effects that
raloxifene has on preventing breast cancer. Until those studies are
complete, the drug remains one that is only prescribed to women at risk for
osteoporosis.
That's fine for some women's advocates who want more proof before jumping on
the raloxifene bandwagon. "It's far too soon to say that raloxifene prevents
breast cancer," says Cindy Pearson of the nonprofit National Women's Health
Network.
iVillage and Better Health are trademarks of iVillage, Inc.
Your friend Lillian
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