Re: [MOL] tamoxifen side effects? [05950] Medicine On Line


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Re: [MOL] tamoxifen side effects?



For more than 20 some year's tomoxifen has been used to treat postmem.women
as a therapy to reduce the reoccurance of cancer.  The drug has helped many
a women, some of whom are on this line; however no two people are alike and
the side effects should one's body not respond well to the drug are just as
serious.  Leg cramps, blod clots and more.  Have they checked your mother's
thyroid gland?  This little old gland is often over looked and can create
havoc on the system.  I had some very serious side effects to tomoxifen and
have heard of many others who also have; but have heard from equally as many
that they haven't.  There is another drug that works equally as well as
tomoxifen with far fewer side effects and I have attached all information
for you.  If we may help you in any other way. know that this is one
wonderful caring forum that are here for those cancering or care givers and
friends to those cancering.  Pls. keep us posted on your mother.  Sincerely,
Lillian


-----Original Message-----
From: L Bosse <bosse@aug.com>
To: mol-cancer@lists.meds.com <mol-cancer@lists.meds.com>
Date: Monday, May 11, 1998 1:45 PM
Subject: [MOL] tamoxifen side effects?


>Can anyone shed light on the side-effects of tamoxifen?  My mother was fine
>until a mastectomy in Jan. to remove a stage 1 cancer with no lymphatic
>involvement.  Her physicians put her tamoxifen as a precursor to chemo.  26
>days ago she was admitted to the hospital with extreme pain in her legs,
>thighs and arms and fever.  The fever has cleared, but the muscle pains
>remain and she's usually on morphine.  Since her hospitalization, she's
>developed a blood clot in her R leg, which was treated with heparin and
>now, coumadin.  Her blood sugar is out of whack, and everything from Lyme
>disease to bone cancer has been ruled out.  I can't help thinking that
>there was something the tamoxifen triggered in her system, something like a
>fibro-neuralgia.  Anyone experience anything similar?
>
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---- Begin included message ----
Another positive message of Progress in cancer treatments.  I am

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God Bless

marty auslander







HERCEPTIN SUBMITTED TO TREAT BREAST CANCER.



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specialist who conducted the South Florida study.



Orange County Register dtd 4/11/98
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---- Begin included message ----
Tamoxifen and Raloxifene: Making Sense of the New Breast Cancer Drugs

by Samme Chittum
Just when women thought they knew the ups and downs of tamoxifen, the first
drug found to prevent breast cancer, another drug, raloxifene, is now front
page news as well.
Raloxifene, sold under the brand name "Evista" (made by Eli Lilly and Co.),
is prescribed to help prevent osteoporosis, a chronic, debilitating
condition in which bones weaken and deteriorate.
But now raloxifene is in the spotlight for another reason. Preliminary data
released by the National Cancer Institute shows raloxifene may also offer
the same breast cancer preventing protection of tamoxifen -- a 50 percent
reduced rate of cancer in clinical trials; but without tamoxifen's
downside -- an increased risk of uterine cancer.
"The safety profile of Evista is very high compared to tamoxifen," says Dr.
Maurice Cohen, director of the Women's Health Program at North Shore
Diabetes and Endocrine Associates in New York.
What's the difference between the two drugs, and how will you know if either
one is right for you? The main distinction is that while tamoxifen has been
FDA approved as a breast cancer prevention medication, it has potentially
serious risks. And raloxifene, which has only a few side effects such as leg
cramps or possible blood clots in the legs, has only been approved to help
prevent osteoporosis and lower cholesterol in postmenopausal women. That it
might also have the added benefit of reducing a woman's risk of breast
cancer is possible, but not yet certain.
Nevertheless, some doctors are hopeful about raloxifene's numerous potential
benefits.
"With raloxifene, you're getting a lot of bang for you medical dollar," says
Dr. Steven Goldstein, a gynecologist at New York University Medical Center.
While this may be true, researchers are still studying the effects that
raloxifene has on preventing breast cancer. Until those studies are
complete, the drug remains one that is only prescribed to women at risk for
osteoporosis.
That's fine for some women's advocates who want more proof before jumping on
the raloxifene bandwagon. "It's far too soon to say that raloxifene prevents
breast cancer," says Cindy Pearson of the nonprofit National Women's Health
Network.
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Your friend Lillian
---- End included message ----

Welcome Ca..doc