Re: [MOL] information - octreotide [02637] Medicine On Line


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Re: [MOL] information - octreotide



Thanks Lil. That was an excerpt from one of your marvelous educational
series. See, I do save them!
Christine

At 07:50 PM 27/12/98 -0500, you wrote:
>Christine, go girl, that was a good report you sent....your friend, lillian
>
>----------
>> From: Christine White <christine.white@sympatico.ca>
>> To: mol-cancer@lists.meds.com
>> Subject: Re: [MOL] information - octreotide
>> Date: Sunday, December 27, 1998 7:30 PM
>> 
>> Here is an excerpt about some of the risks of octreotide. One of them
>does
>> have to do with the thyroid. Hope this is of some help.
>> 
>> Christine
>> 
>> 
>> Risks Associated with Octreotide:   Octreotide may produce reactions at
>the
>> site of your shot, including pain, redness, and swelling. Diarrhea is a
>> common side effect that often decreases over time, even when patients
>> receive additional doses of octreotide. The diarrhea can usually be
>managed
>> with anti-diarrheal drugs. Other possible reactions to octreotide include
>> nausea, vomiting, abdominal pain and bloating, decreased absorption of
>fat,
>> constipation, and increased gas.
>> 
>> Patients taking octreotide are thought to be more likely to develop
>> gallbladder problems, including gallstones and bile problems. It is
>> estimated that 20-30% of patients taking octreotide may develop
>gallstones.
>> Additional patients (25-35%) may develop bile problems without
>gallstones.
>> Many patients taking octreotide have nausea, vomiting, abdominal
>> discomfort, and gas (as noted in the previous paragraph), even without
>> gallbladder problems. Symptoms of gallbladder disease include abdominal
>> pain (often beginning within a few hours after meals), nausea, vomiting,
>> fever, and yellowing of the skin. Bloating, belching, gas, and
>intolerance
>> for fatty foods may occur but are not specific for gallbladder problems.
>> Gallbladder inflammation, gallbladder infection, inflammation of the
>liver
>> and/or pancreas may occur. Some patients may require hospitalization and
>> possibly surgery to remove their gallbladder. A few patients taking
>> octreotide have had life-threatening side effects. Rarely, death has
>> occurred. Gallbladder and bile symptoms may develop after octreotide is
>> discontinued. Patients who are known to have gallstones before taking
>> octreotide can enter this study if they have never had symptoms. It is
>not
>> known whether these patients with gallstones at the start of the study
>will
>> be at more risk for developing symptoms from gallstones than patients who
>> develop gallstones or bile problems after entering the study.
>> 
>> Octreotide may cause low or high blood sugar in patients with diabetes as
>> well as in non-diabetic patients, though the risk may be greater in
>> diabetics. When compared with non-diabetic patients, diabetic patients,
>> diabetic patients receiving insulin are at more risk for low blood sugar,
>> which can be life-threatening. Your doctor may need to prescribe new
>> medication(s), or change the dose of medication(s) you already take for
>> diabetes. Octreotide may cause decreased thyroid function. Your doctor
>may
>> need to prescribe new medication(s), or change the dose of medication(s)
>> you already take for thyroid problems. Changes in heart rhythm have been
>> reported in patients with a specific hormone disorder (called acromegaly)
>> who were being treated with octreotide. Changes in the dose of some blood
>> pressure or heart medications may be necessary. In addition, decreased
>> vitamin B12 levels, flushing, dizziness and lightheadedness, fatigue,
>> headache, body aches, hair thinning/loss, allergic reactions, and
>> occasional water retention can occur.
>> 
>> It is not known whether octreotide will increase, decrease, or have no
>> effect on the rate of uterine cancer in patients taking tamoxifen. 
>> 
>> >----------
>> >> From: hardset <hardset@k0r3dump.org>
>> >> To: mol-cancer@lists.meds.com
>> >> Subject: [MOL] information
>> >> Date: Wednesday, January 03, 1996 1:02 PM
>> >> 
>> >> Hi,
>> >> 
>> >> My mother is taking the octreotide injection for the clinicaltrial,
>for a
>> >> year and seven months.  She has had radiation and is on tamoxen.  Her
>> >> breast cancer was hormone positive and in the last six months she has
>> >been
>> >> losing weigth and her thyroid is not functioning.  I am worried and
>would
>> >> really appreciate any information on the octreotide injection and how
>> >other
>> >> patients are responding in the trial.  The more education we can
>receive
>> >> the better.  
>> >> 
>> >>                              Thank you for your cooperation.  Monique
>> >> Alexander
>> >>               337 read ave.
>> >>               Espanola, Ont.,
>> >>               P5E 1E2
>> >> 
>> >>
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