Dear CAroline,
Just read about what you wrote to PJ about the potential and posssible
harmful effects of processed sugar and sugar from too much juicing of
fruit and the benefits of water and juicing of veggies. Good for you and
yes I do remember. Thank you and God Bless
marty auslander
The Wilcott Family wrote:
>
> Hi Martin,
> Went through my saved e-mails and came across this posting of yours. We
> were just recently talking about the wine/grape juice thing, remeber?
> Sincerely,
> Caroline from Canada
>
> ----------
> > From: Martin Auslander <fitecancer@earthlink.net>
> > To: Medical On Line Forum <mol-cancer@lists.meds.com>
> > Subject: [MOL] Researchers Report Mechanism for Anti-Clotting Effects
> > Date: November 27, 1998 7:37 AM
> >
> > Good Morning My FRiends,
> >
> > Just received this from a very knowledgable friend whom I have been
> > internetting communicating on his website. HOpe the following
> > information benefits.
> >
> > "Dear Folks,
> >
> > There is a company that I've been in past communication with that offers
> > a capsule with grape leaves. They are very nice people."
> >
> > You can review what they offer at http://www.grapeheart.com/
> >
> > Flavonoids Found in Purple Grape Juice Thought to Increase Nitric Oxide
> > Levels
> >
> > While Reducing Free Radical Production
> >
> > DALLAS, Nov. 10 /PRNewswire/ -- The so-called French Paradox seems a
> > little less mysterious today as researchers reported that flavonoids
> > found in purple grape juice, also found in red wine, stimulate platelet
> > production of nitric oxide -- a chemical which plays a role in
> > inhibiting platelet aggregation and thrombus formation. Preliminary
> > studies in both humans and animals have previously reported the effects
> > of drinking purple grape juice on platelet aggregation. Studies have
> > reported similar anti-platelet effects for red wine. The mechanisms
> > behind these potentially beneficial effects, however, are not fully
> > understood.
> >
> > In a laboratory study presented today at the 71st Scientific Sessions of
> > the American Heart Association, Jane E. Freedman, M.D., assistant
> > professor of medicine and pharmacology at Georgetown University Medical
> > Center, found that blood platelets bathed in a dilute solution of purple
> > grape juice released three times more nitric oxide (NO) than those in a
> > control group.
> >
> > "The process by which coronary artery disease progresses is
> > multifactorial and extremely complicated. Nonetheless, these findings
> > are significant for a number of reasons," Freedman explains. "First,
> > there is a growing understanding that a reduction in nitric oxide
> > production, which normally comes from both the platelets and from the
> > endothelial lining of the blood vessel, contributes to platelet
> > aggregation and thrombus formation. In patients with coronary artery
> > disease, for example, their platelet and blood vessel nitric oxide
> > production appears to be lower than in healthy subjects."
> >
> > At the same time, Freedman found that platelets bathed in purple grape
> > juice also released 55% less superoxide -- a free radical -- than
> > platelets in the control solution.
> >
> > "We also believe that the release of superoxide contributes to thrombus
> > formation as well, by rendering the nitric oxide ineffective. Thus, a
> > patient with coronary artery disease who has low levels of nitric oxide
> > and high levels of superoxide may be likelier to experience a
> > potentially dangerous thrombus formation than a person with normal
> > levels. Seeing the ability of purple grape juice to increase nitric
> > oxide production combined with its ability to suppress superoxide
> > production gives us a better understanding of why drinking purple grape
> > juice may support healthy cardiovascular function."
> >
> > Finally, Freedman was able to show the beneficial effects of a specific
> > flavonoid called quercetin, one of many polyphenolic compounds found in
> > purple grape juice. She found that platelet incubation with quercetin
> > inhibited PMA-induced stimulation of protein kinase C -- a pathway by
> > which platelet aggregation is increased.
> >
> > "There have always been questions about the role of alcohol in the
> > health benefits of drinking red wine," says Freedman. "However, it
> > carries with it its own set of problems and concerns. Isolating the
> > effects of quercetin is important because it suggests that purple grape
> > juice may be a legitimate, non-alcoholic alternative to red wine."
> >
> > Freedman's co-authors on the study are Ryan Sauter, B.S., Georgetown
> > University Medical Center, and John D. Folts, Ph.D., University of
> > Wisconsin Medical School.
> >
> > For more information:
> >
> > Please see AHA Press Release: "The heart-healthy cup runneth over --
> > with grape juice" at www.amhrt.org. Contact AHA press office at
> > 214-853-8056. Dr. Freedman is also available for interviews on Monday
> > through that office.
> >
> > Dr. Freedman's research is being presented as a poster at the AHA. See
> > poster #1558, November 10, 1998, from 1:30 P.M. -- 5:00 P.M.
> >
> > Of related interest is AHA abstract #1559 entitled: "a-Tocopherol
> > Increases Platelet-Derived Nitric Oxide Release."
> >
> > Editorial usage notes:
> >
> > 1. The research studied the effect of nitric oxide (NO), which is
> >
> > different from but often confused with nitrous oxide (NO2), the
> >
> > so-called laughing gas.
> >
> > 2. Research often refers to "red" grape products as a way to
> >
> > differentiate them from white grape products. This should not be
> >
> > translated into "red" grape juice. Much of the research in this
> >
> > field, including Dr. Freedman's, has been conducted using juice made
> >
> > from Concord grapes, which produces purple grape juice.
> >
> > ABSTRACT
> >
> > Purple Grape Juice Inhibits Platelet Function and
> >
> > Increases Platelet-Derived Nitric Oxide Release
> >
> > Ryan Sauter, Georgetown University Medical Center, Washington, DC; John
> > D. Folts, University of Wisconsin Medical School, Madison, WI; Jane E.
> > Freedman, Georgetown University Medical Center, Washington, DC
> >
> > Background: Moderate red wine consumption is inversely associated with
> > coronary ischemia. Red wine and purple grape juice (GJ) contain
> > flavonoids with antioxidant and anti-platelet properties believed to be
> > protective against cardiovascular events. Acute cardiac events, caused
> > by platelet activation and thrombosis, are also associated with
> > decreased platelet-derived nitric oxide (NO) release. Therefore, we
> > investigated the effect of GJ on platelet NO release. Methods and
> > Results: Platelet aggregation was significantly inhibited after
> > incubation with a 1:1000 dilution of GJ as compared to vehicle control
> > (58.3% plus/minus 6.0% vs. 88.3% plus/minus 4.4%, P<0.01, n=3).
> > Platelet-derived NO release was measured with an electrochemical
> > detector adapted for use in a standard aggregometer. Incubation of human
> > platelets with a 1:1000 dilution of GJ increased NO release as compared
> > to control (1.5 plus/minus 0.2 pmol/108 platelets vs. 0.5 plus/minus 0.1
> > pmol/108 platelets, P=0.01, n=4). Because NO interacts with superoxide,
> > we measured superoxide release in platelets incubated with GJ. Platelets
> > incubated with GJ had a 55% decrease in platelet release of superoxide
> > as compared to control (P<0.01, n=4). In addition, red grape products
> > are rich in the flavonoid quercetin. Platelet incubation with quercetin
> > inhibited PMA-induced stimulation of platelet protein kinase C (PKC) as
> > determined by phosporylation of the 47-kD PKC substrate. Conclusion:
> > These data indicate that the flavonoids in purple grape juice are a
> > potent inhibitor of platelet function and increase platelet-derived NO
> > release through antioxidant- and PKC-dependent mechanisms. These
> > observations represent a potential mechanism for the beneficial effects
> > of red grape products in cardiovascular disease.
> >
> > SOURCE Scientific Sessions of the American Heart Association
> >
> > -----------------------------
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