Re: [MOL] ewings sarcoma any new information [02498] Medicine On Line

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Re: [MOL] ewings sarcoma any new information

ellen erickson-accardi wrote:
>     ---------------------------------------------------------------

Dear Ellen...hope the attached sheds some light on Ewings Sarcoma.  I 
would suggest calling 1-800-4CANCER for any of the latest in Clinical 
Trial informantion or go to
Best of luck and don't lose faith and hope.  God Bless. John
Title: Ewing's sarcoma/primitive neuroectodermal tumor (PNET)

Ewing's sarcoma/primitive neuroectodermal tumor (PNET)


Check the Options
Ewing's sarcoma/primitive neuroectodermal tumor (PNET) PDQ Statement for Health Professionals

CancerNet from the National Cancer Institute

Information from PDQ for Patients


What is PDQ?
PDQ is a computer system that provides up-to-date information on cancer and its prevention, detection, treatment, and supportive care. PDQ is a service of the National Cancer Institute (NCI) for people with cancer and their families and for doctors, nurses, and other health care professionals.

To ensure that it remains current, the information in PDQ is reviewed and updated each month by experts in the fields of cancer treatment, prevention, screening, and supportive care. PDQ also provides information about research on new treatments (clinical trials), doctors who treat cancer, and hospitals with cancer programs. The treatment information in this summary is based on information in the PDQ summary for health professionals on this cancer.

How to use PDQ
Cancer in children is rare. The majority of children with cancer are treated at cancer centers with special facilities to treat childhood cancers. There are organized groups of doctors and other health care professionals who work together by doing clinical trials to improve treatments for children with cancer.

PDQ can be used to learn more about current treatment of different kinds of cancer. You may find it helpful to discuss this information with your child's doctor, who knows your child and has the facts about your child's disease. PDQ can also provide the names of additional health care professionals and hospitals that specialize in treating children who have cancer.

Before your child begins treatment, you may want to consider entering your child in a clinical trial. PDQ can be used to learn more about the trials. A clinical trial is a research study that attempts to improve current treatments or find new treatments for people with cancer. Clinical trials are based on past studies and information discovered in the laboratory. Each trial answers specific scientific questions in order to find new and better ways to help people with cancer. During clinical trials, information is collected about new treatments, their risks, and how well they do or do not work. When a clinical trial shows that a new treatment is better than the treatment currently used as "standard" treatment, the new treatment may become the "standard" treatment. Children who are treated in clinical trials have the advantage of getting the best available therapy. In the United States, about two thirds of children with cancer are treated in a clinical trial at some point in their illness.

Listings of current clinical trials are available on PDQ. In the United States, there are two major groups (called cooperative groups) that organize clinical trials for childhood cancers: the Childrens Cancer Group (CCG) and the Pediatric Oncology Group (POG). Doctors who belong to these groups or who take part in other clinical trials are listed in PDQ.

To learn more about cancer and how it is treated or to learn more about clinical trials for your child's kind of cancer,

  • call the National Cancer Institute's Cancer Information Service. The number is 1-800-4-CANCER (1-800-422-6237)
    • TTY at 1-800-332-8615
    The call is free and a trained information specialist will be available to answer your cancer-related questions.

    PDQ is updated whenever there is new information. Check with the Cancer Information Service to be sure that you have the most up-to-date information.


    What is Ewing's sarcoma/primitive neuroectodermal tumor?
    Ewing's sarcoma/primitive neuroectodermal tumor is a rare disease in which cancer (malignant) cells are found in the bone. The most common areas in which it occurs are the pelvis, the thigh bone (femur), the upper arm bone (humerus), and the ribs. Ewing's sarcoma/primitive neuroectodermal tumor most frequently occurs in teenagers.

    Osteosarcoma is another kind of bone cancer, but the cancer cells look different under a microscope than Ewing's sarcoma/primitive neuroectodermal tumor cancer cells. If you want information on osteosarcoma, refer to the PDQ patient information statement on osteosarcoma.

    Like most cancers, Ewing's sarcoma/primitive neuroectodermal tumor is best treated when it is found (diagnosed) early. If a patient has symptoms (such as pain, stiffness, or tenderness in the bone) the doctor may order x-rays and other tests. The doctor may also cut out a piece of tissue from the affected area. This is called a biopsy. The tissue will be looked at under a microscope to see if there are any cancer cells. This test may be done in the hospital.

    The chance of recovery (prognosis) and choice of treatment depend on the location, size, and stage of the cancer (how far the cancer has spread), how the cancer cells react to the treatment, and the patient's age and general health.


    Stages of Ewing's sarcoma/primitive neuroectodermal tumor
    Once Ewing's sarcoma/primitive neuroectodermal tumor has been found, more tests will be done to find out if cancer cells have spread to other parts of the body. This is called staging. At present, there is no formal staging system for Ewing's sarcoma/primitive neuroectodermal tumor. Instead, most patients are grouped depending on whether cancer is found in only one part of the body (localized disease) or whether cancer has spread from one part of the body to another (metastatic disease). Your doctor needs to know where the cancer is located and how far the disease has spread to plan treatment. The following groups are used for Ewing's sarcoma/primitive neuroectodermal tumor:

    The cancer cells have not been shown to have spread beyond the bone in which the cancer began or are found only in the bone and nearby tissues.

    The cancer cells have spread from the bone in which the cancer began to other parts of the body. The cancer most often spreads to the lung, other bones, and bone marrow (the spongy tissue inside of the large bones of your body that makes red blood cells). Spread of cancer to the lymph nodes (small bean-shaped structures found throughout your body which produce and store infection-fighting cells) or the central nervous system (brain and spinal cord) is less common.

    Recurrent disease means that the cancer has come back (recurred) after it has been treated. It may come back in the tissues where it first started or it may come back in another part of the body.


    How Ewing's sarcoma/primitive neuroectodermal tumor is treated
    There are treatments for all patients with Ewing's sarcoma/primitive neuroectodermal tumor. Three kinds of treatment are used:
    surgery (taking out the cancer in an operation) radiation therapy (using high-dose x-rays to kill cancer cells) chemotherapy (using drugs to kill cancer cells)

    Surgery may be used in certain cases to try to remove the cancer and some of the tissue around it. Surgery may also be used to remove any tumor that is left after chemotherapy or radiation therapy.

    Radiation therapy uses x-rays or other high-energy rays to kill cancer cells and shrink tumors. Radiation for Ewing's sarcoma/primitive neuroectodermal tumor usually comes from a machine outside the body (external radiation therapy). Clinical trials are evaluating radiation given inside the body during surgery (intraoperative radiation therapy).

    Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill, or it may be put into the body by a needle in a vein or muscle. Chemotherapy is called a systemic treatment because the drug enters the blood stream, travels through the body, and can kill cancer cells throughout the body. When more than one drug is given to kill tumor cells, the treatment is called combination chemotherapy. For treating Ewing's sarcoma/primitive neuroectodermal tumor, surgery or radiation is often used to remove the local tumor and chemotherapy is then given to kill any cancer cells that remain in the body.

    Treatment by stage
    Treatment for Ewing's sarcoma/primitive neuroectodermal tumor depends on where the cancer is located, how far the cancer has spread, the stage of the disease, and the age and general health of the patient.

    A patient may receive treatment that is considered standard based on its effectiveness in a number of patients in past studies, or may choose to go into a clinical trial. Not all patients are cured with standard therapy and some standard treatments may have more side effects than are desired. For these reasons, clinical trials are designed to find better ways to treat cancer patients and are based on the most up-to-date information. Clinical trials for Ewing's sarcoma/primitive neuroectodermal tumor are going on in many parts of the country. If you want more information, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237)

  • TTY at 1-800-332-8615


Treatment for localized Ewing's sarcoma/primitive neuroectodermal tumor depends on where the cancer is found in the body.

If the cancer is in the bone below the elbow or knee or in the jaw, skull, face, shoulder blade, collar bone, or segments of the spinal column, treatment may be one of the following:

1. Combination chemotherapy
2. Surgery and combination chemotherapy.
3. Radiation therapy and combination chemotherapy.
4. A clinical trial of chemotherapy and new ways of giving radiation therapy.
5. A clinical trial of chemotherapy followed by surgery, with or without radiation therapy.

Clinical trials are also evaluating new doses and combinations of chemotherapy.


Treatment may be one of the following:

1. Combination chemotherapy.
2. Radiation therapy plus combination chemotherapy.
3. Combination chemotherapy plus surgery to remove cancer that has spread to the lungs.

Clinical trials are evaluating new doses and combinations of chemotherapy with or without radiation treatment.


Treatment depends on where the cancer recurred, how the cancer was treated before, and individual patient factors. Radiation treatment may be given to reduce symptoms. Clinical trials are testing new treatments.