I have given you many sites for you to explore for your answers. If we
may be of further help to you pls. know that we are here and you are
always welecomed. Your friend, lillian
THE MERCK MANUAL
The Sixteenth Edition of The Merck Manual was
published in 1992,
and many parts of this version are now out of date
with current
medical practices.
SECTION 9. HEMATOLOGY AND
ONCOLOGY
93. ANEMIAS
ANEMIAS DUE TO DEFICIENT ERYTHROPOIESIS
HYPOPLASTIC (APLASTIC) ANEMIAS
Etiology and Pathogenesis
True aplastic anemia is uncommon; about ½ of cases
are idiopathic; they
are most common in adolescents and young adults. In
the rest, the cause
can be a chemical (eg, benzene, inorganic arsenic),
radiation, or drugs (eg,
antineoplastics). Many drugs (eg, antibiotics,
anti-inflammatory drugs,
anticonvulsants) have been implicated in individual
cases. The mechanism
of such events is unknown, but a selective (perhaps
genetic)
hypersensitivity appears to be the basis. A very
rare form of aplastic
anemia, Fanconi's anemia (a type of familial
aplastic anemia with bone
abnormalities, microcephaly, hypogenitalism, and
brown pigmentation
of skin) occurs in children with abnormal
chromosomes. Finally, it should
be noted that marrow hypoplasia may be found in the
elderly. Although
long suggested that aging results in hypoplasia,
that finding has not been
confirmed. In the elderly, stress (acute infections
or inflammatory events)
may result in peripheral cytopenias because of their
limited marrow
reserve. With clearing of the interval event,
peripheral values return to
normal in spite of the reduced marrow mass.
Pure RBC aplasia, on the other hand, implies a
mechanism selectively
destructive to the erythroid precursors; other
hematopoietic elements are
unaffected. Clinical correlations exist with some
cases of RBC aplasia but
the pathophysiologic mechanisms are unknown. Thus,
acute
erythroblastopenia is well known to be a brief
reversible disappearance of
RBC precursors in the marrow during a variety of
acute viral illnesses,
especially in children. Infection with human
parvovirus appears to be the
most common cause of this event. Indeed, this may be
recognized
fortuitously, since the sequela of aplasia (ie,
anemia) requires a duration
longer than usually exists with the acute episode.
Chronic RBC aplasia
has been associated with thymomas, immunologic
injury, and less often
with drugs (tranquilizers, anticonvulsants, etc),
toxins (organic phosphates),
riboflavin deficiency, and chronic lymphocytic
leukemia. A rare congenital
form, Blackfan-Diamond syndrome, is described.
Although it was
originally believed to be manifested during infancy,
cases are known in
which these changes develop in adulthood --the
presence of related bony
abnormalities of the thumbs or digits and short
stature help to identify them.
Erythroid aplasia may occur transiently during
various infections and
hemolytic disorders (aregenerative crisis, acute
erythroblastopenia), and in
association with tumors of the thymus.
MEDIC APLASTIC ANEMIA POST TEST
Test on Aplastic Anemia. Questions 1-6. Choose the single best answer..
Patients presenting with aplastic anemia may exhibit all of the
following
except: A. pallor B. bruising C. retinal ...
91% Date: 22 Mar 1996, Size 3.9K,
http://medic.med.uth.tmc.edu/edprog/00000609.htm
***See more pages from this site
Specific Disease Category Listing (282)
CenterWatch Listing of Clinical Research Trials for Aplastic Anemia
CenterWatch, clinical,
research, trials, diseases, drugs, therapies, medical, health, patients,
drug testing, FDA, pha
...
88% Date: 11 Aug 1998, Size 3.7K,
http://www.centerwatch.com/studies/CAT282.HTM
THE MERCK MANUAL - HYPOPLASTIC (APLASTIC) ANEMIAS;Etiology and
Pathogenesis
THE MERCK MANUAL The Sixteenth Edition of The Merck Manual was published
in 1992,
and many parts of this version are now out of date with current ...
87% Date: 21 Aug 1998, Size 9.9K,
http://www.merck.com/!!ulchn2kE4ulchn2kE4/pubs/mmanual/html/kmlggcgh.htm
***See more pages from this site
Aplastic anemia is not a simple disease, even when diagnosed
Dr. Paul Donohue We recently lost a dear friend from aplastic anemia.
She was in apparent
good health, taking no medication, and at 67 able to walk her two miles
daily. She ...
87% Date: 1 Nov 1996, Size 4.3K,
http://www.detnews.com/menu/stories/21193.htm
Improvement in Anemia by Recombinant Human Erythropoietin in Patients
With
Myelodysplastic ...
Improvement in Anemia by Recombinant Human Erythropoietin in Patients
With
Myelodysplastic Syndrome and Aplastic Anemia......
87% Date: 21 May 1998, Size 8.7K,
http://www.noblood.com/wf/articles/00200511.htm
***See more pages from this site
Aplastic Anemia Foundation to hold International Conference
Conference Schedule. Friday, August 8, 1997. 2:00 PM Registration
3:00-4:00 PM Patient,
Spouse, Parent or Bereavement Workshops Facilitated by professional
therapists. This is ...
85% Date: 3 Apr 1997, Size 2.9K,
http://www.teleport.com/nonprofit/aafa/schedule.html
***See more pages from this site
Harmening Chap 8: Aplastic Anemia Fall 1997 Definition = failure of
production of erythrocytes, platelets, & leukocytes Causes = Radiation,
chemicals, drugs,
infections & autoimmune syndromes I. Pathogenesis A. Peripheral
pancytopenia 1. Direct
damage to stem cells is indicated from radiation or exogenous ...
84% Date: 24 Sep 1997, Size 6.7K,
http://www.sonoma.edu/biology/hanes/b484/APLAST8.HTM
***See more pages from this site
Suspension of Felbatol Use Urged
The Food and Drug Administration today recommended the immediate
withdrawal of patients
from the antiepilepsy drug Felbatol because it has been linked to 10
cases of aplastic anemia.
In a "Dear Doctor" ...
84% Date: 17 Feb 1998, Size 2.1K,
http://www.fda.gov/bbs/topics/NEWS/NEW00488.html
Withdrawal from Felbamate Therapy Recommendeds
Medical Sciences Bulletin Contents Withdrawal from Felbamate Therapy
Recommended.
Reprinted from the September 1994 issue of Medical Sciences Bulletin ,
published by
Pharmaceutical ...
84% Date: 7 Aug 1998, Size 3.9K,
http://pharminfo.com/pubs/msb/felbam.html
***See more pages from this site Re: MDS Aplastic Anemia, Lukemia
[ Follow Ups ] [ Post Followup ] [ ASK DR STOLL ] [ FAQ ] [ DR STOLL'S
BOOK ] Posted by james on March 21, 1998 at 17:31:37: In Reply to: Re:
MDS Aplastic Anemia, Lukemia posted by Walt Stoll on ...
84% Date: 1 May 1998, Size 3.2K,
http://bcn.net/~stoll/wwwboard/messages/2590.html
***See more pages from this site
NE AAFA
The Aplastic Anemia Foundation of America - New England Region
(AAFA-NER) Home Page . AAFA - NER P.O. Box 1645 Brookline, MA
02146 1-800-257-2232 AAFA-NER is the New England chapter of the
Aplastic Anemia Foundation of ...
83% Date: 13 Jun 1998, Size 2.5K, http://www.cris.com/~Vmwlbw/
September 1996 - SMJ: Allogeneic Bone Marrow Transplantation
Allogeneic Bone Marrow Transplantation . Imad A. Tabbara, MD,
Washington, DC .
ABSTRACT: Allogeneic bone marrow transplantation (BMT) after high-dose,
marrow-ablative
chemoradiotherapy ...
83% Date: 12 Mar 1998, Size 62.8K, http://www.sma.org/smj/96sept3.htm
JAMA 1992 Apr 15: Aplastic anemia and viral hepatitis. Non-A, Non-B, ...
Is there a storm in your future? Get your 5-day forecast. enter zip here
Aplastic anemia and
viral hepatitis. Non-A, Non-B, Non-C? JAMA 1992 Apr 15;267 ...
83% Date: 24 Jul 1998, Size 9.9K,
http://www.thriveonline.com/health/Library/CAD/abstract5521.html
***See more pages from this site
Haematological Malignancies: Leukaemia, Lymphoma, Multiple Myeloma, etc.
This page provides extensive links to information about leukaemia,
lymphomas, and other
haematological malignancies. Resources of interest to patients and
physicians are listed by
...
81% Date: 25 Jun 1998, Size 66.8K,
http://www.ncl.ac.uk/~nchwww/guides/clinks2.htm
***See more pages from this site
Nov 96 Bipolar and Aplastic
Ask the Expert - Bipolar Disorder and Aplastic Anemia. Q. I am
manic-depressive. In June,
my doctor put me on Depakote to stabilize the mood swings. Over a long
period of time
without any side effects, my ...
80% Date: 25 Aug 1998, Size 6.3K,
http://www.mhsource.com/expert/exp1110496j.html
7/31/98 -- 9:37 PM. Boy hopes for transplant to `lead a normal life ...
7/31/98 -- 9:37 PM. Boy hopes for transplant to `lead a normal life
again' By BRIAN GELLER
of The Tampa Tribune CLEARWATER - A 12-year-old boy stricken with
aplastic ...
80% Date: 8 Aug 1998, Size 5.9K,
http://www.tampatrib.com/news/satu102c.htm
BCMD Issue 14
Issue 14 (July 31, 1996) Volume 22 of Blood Cells, Molecules, & Diseases
(ISSN 1079-9796)
Sham, R.L., Phatak, P.D., Belanger, K.A., Packman, C.H. - The Effect of
Dexamethasone on
Functional Properties of HL60 Cells ...
80% Date: 1 Aug 1996, Size 8.1K,
http://seconde.scripps.edu/is199614.html
Chapter 4
Allogeneic Bone Marrow Transplants. DISEASES FREQUENTLY TREATED WITH
ALLOGENEIC BMTS. Aplastic Anemia Hodgkin's Disease Leukemia
Myelodysplasia
Non-Hodgkin's Lymphoma Multiple Myeloma Osteopetrosis Severe Combined
Immune
Deficiency ...
80% Date: 29 Jan 1998, Size 27.3K,
http://nysernet.org/bcic/bmt/bmt.book/chapter.4.html
Iron-Poor Blood Can Drag You Down
An article about women and anemia.
80% Date: 23 Aug 1998, Size 6.9K,
http://www.sk.sympatico.ca/Contents/Health/HEALTHYWAY/womens_1.html
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