[MOL] Attn: Bob Hangsterfer, Prostate cancer, Seed Implants [01941] Medicine On Line


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[MOL] Attn: Bob Hangsterfer, Prostate cancer, Seed Implants



Dear Bob:  

Use "Radioactive Seed Implants" as your search criteria, you will come
up with plenty on the Internet.  My father had this type of therapy 15
years ago at Sloan Kettering in NYC - It did not "cure" him, but his
doctors claimed it slowed the progression of the disease.  Diagnosed at
65, my dad died of the effects of prostate cancer at 73.  I have learned
a lot about prostate cancer and the treatments options and now believe
that while the treatments he underwent (seed implants, hormone
ablatement therapy, radiation treatment for bone mets, and castration)
may have changed the progression of his disease, these treatment did not
extend his life or improve his quality of life.  

I now work with Dr. I. William Lane, Ph.D. in the research using shark
cartilage (a file is attached with more information), because I have
come to realize that therapies that focus on strengthening the body's
own defenses, keeping patients alive, with a high quality of
life(typically non-toxic therapies) are more successful than aggressive
therapies that aim to "Kill" the cancer.  We have a network of cancer
survivors, including many men with prostate cancer who would be willing
to speak with you or your father about the therapies they have
undergone, and their knowledge of living with prostate cancer.  If you
would like the names and phone numbers of these people, please call
Marian Murphy at Cartilage Consultants in Connecticut, (phone
860-628-6061).  She can also answer questions about shark cartilage
research and help you locate doctors with experience using natural and
nutritional medicine in patients with prostate cancer.

Best wishes,
David Wales
Answers to the Most Important Questions About Shark Cartilage
 by I. William Lane, Ph.D. (c) Copyright 1997 Cartilage Consultants, Inc.

The approaches described by Dr. Lane in this communication are not offered as cures, 
prescriptions, diagnoses, or a means of diagnosis to different conditions.  The 
information must be viewed as an objective compilation of existing data and 
research.  Dr. Lane assumes no responsibility in the correct or incorrect use of this 
information and no attempt should be made to use any of this information without 
the approval and guidance of your doctor.

1. What is shark cartilage?

In most animals the skeleton is made of calcified bone, and cartilage is a flexible 
tissue, the "gristle," found between bones,  but in sharks the entire skeleton is 
composed of cartilage.  Shark cartilage supplements are derived from the 
skeletons of sharks caught as food.  The meat, nerve and blood vessel tissue that 
surrounds the skeleton is removed and the remaining cartilage is dried and 
pulverized. 

2. How does shark cartilage work?

Natural whole shark cartilage is composed of proteins, carbohydrates, 
mucopolysaccharides,  glucosamine sulphate, chondroitin sulphate, calcium, 
phosphorus, zinc, magnesium and other minerals.  Each of these components has 
beneficial properties effecting a variety of medical conditions, so shark cartilage 
can be said to "work" on many levels.  

Proteins in shark cartilage inhibit the development of blood vessels, which support 
tumor growth.  Immune stimulation and anti-inflammatory  effects are attributed to 
macroproteins, mucopolysacchrides, chondroitin and glucosamine sulfates.  The 
ratio of minerals in shark cartilage is nearly identical to that found in human bones, 
so shark cartilage is an ideal supplement to maintain proper joint function.  
Minimum daily nutritional requirements have been established for these minerals 
and the use of supplements to attain higher doses is considered beneficial for 
osteoporosis, arthritis, autoimmune disorders, cancer and other medical 
conditions.

3. What is the effect of shark cartilage against cancer?

Shark cartilage attacks cancer by inhibiting the development of the blood vessels 
which supply the food that tumors need to grow - in effect starving tumors of a 
needed blood and food supply. Harvard's Judah Folkman, M.D. identified that the 
establishment of a blood vessel network, a process called angiogenesis, was a key 
phase in the development of cancerous solid tumors. In their avascular (meaning 
without blood vessel) stage of development, tumors are limited to a size of 1 to 2 
cubic millimeters - the size of a pencil point.  Tumors produce chemicals that 
attract capillaries toward them.  Once vascularized and connected to the 
circulatory system, cancers have the fuel for explosive growth, and the means to 
spread throughout the body.  The more vascularized a tumor is, the more 
aggressive it is.  

It has been established that the tumor induced capillary bed is fragile, subject to 
collapse and must constantly be replaced. Researchers reason that because cancer 
cells are hardy and resistant to attack, but the blood  vessels supporting them are 
weak, it makes sense to attack the weak link.  This new treatment mechanism is 
called antiangiogenesis ("anti" meaning against, "angio" meaning blood vessels, 
"genesis" meaning development).  Deny the tumor food, cutoff its roadway to the 
rest of the body, and allow the cancer to wither and die.
  
 Langer and Lee at the Massachusetts Institute of Technology discovered that 
cartilage from several types of animals contains natural angiogenic inhibitors.  
These compounds were found to be proteins and were determined to be 1,000 
times more concentrated in shark cartilage than cartilage from bovine or other 
sources, making shark cartilage the logical cartilage to work with in further 
antiangiogenic research.   Subsequent analysis identified four specific proteins in 
shark cartilage as providing an antiangiogenic effect.

4. Dr. Lane, how did you become involved in the research on shark cartilage?

Over the years, I have worked around the world on the development and 
management of marine resources.  In 1983, when M.I.T. announced its discovery 
about shark cartilage and cancer, I advocated more cancer research using whole 
shark cartilage, but soon learned that many "serious" scientists were interested 
only in studying isolated agents, preferably patented synthetics (pharmaceuticals), 
the profits from which could justify the research investment.  Considering that 
500,000 people a year were dying from cancer in the U.S. at the time, I felt that 
ignoring the promising and available compounds in shark cartilage was callous in 
the extreme, and I determined to pursue research on my own.

5. Can you summarize the research supporting the use of shark cartilage?

In vitro (test tube) and in vivo (animal) studies show that shark cartilage inhibits 
blood vessel formation and has antitumor effects.  Early studies I directed used the 
 CAM assay which measures blood vessel inhibition in developing chick embryos.  
On a scale where "zero" means no inhibition and "two" means complete inhibition, 
various preparations of shark cartilage scored 0.85, 1.1. and higher, compared 
with a potent pharmaceutical inhibitor, heparin/cortisone, which scored 0.75.  
Similar in vitro results have been reported in the skate embryo sac vascular model, 
and in endothelial (blood vessel cell) tissue cultures.  The CAM assay was useful in 
the early days of my research, but is a relatively crude technique.  Recently, I have 
been using strictly biological evaluations, particularly a method developed by Dr. 
Lott at North Texas University which measures effects directly on tumor 
development, and allows comparisons between various cartilage supplements.

M.I.T.'s study was done in rabbits (the rabbit cornea V2 carcinoma model) and 
showed that local application of shark cartilage preparations  inhibited  blood 
vessel development and tumor growth.  My study at the Institute Jules Bordet in 
Brussels showed similar results for oral administration in mice grafted with human 
melanoma.  At 21 days, tumors in mice receiving no treatment were 3 times the 
size and weight of the tumors in mice fed my shark cartilage preparation at a dose 
of 1.2 grams per kilo of body weight for 19 days.  

The U.S. cancer research community did not see the value (or money) in testing a 
whole, natural product, preferring instead to study single agent pharmaceutical 
compounds, so I was forced to conduct human clinical trials in other countries.  At 
a hospital in Mexico, eight patients with advanced, non-responsive tumors (6 
different tumor types) were treated with an extremely concentrated form of shark 
cartilage (91% protein) via retention enema. No adverse effects were noted and at 
11 weeks, and 7 out of 8  patients exhibited positive responses.  Five were tumor 
free, and two had 89% tumor reduction.  The high protein, 91%, and the lack of 
carbohydrates in this product, meant that the effect was coming from the protein, 
not the often touted carbohydrates (mucopolysacchrides).

A larger controlled clinical trial was conducted in Cuba at the top military hospital 
with  29 bed-ridden, terminal patients with stage III and IV cancers, that were non-
responsive to prior therapies (this is the "Cuban Trial" that was investigated and 
reported favorably by the news program "60 Minutes). The 90% protein product 
used in the Mexican study was too expensive and difficult to manufacture for 
mass production, so a 34% protein product was used.  The dosages used were 1 
to 2.25 grams of shark cartilage, per kilo of patient body weight, per day in four 
divided dosages.  For the first 6 weeks, the shark cartilage was administered via 
retention enema, and for an additional 10 weeks either orally or rectally as each 
patient preferred.  

At 16 weeks 15 patients showed improvement based on weight gain, blood 
markers, immune response and Karnofsky index (quality of life measurement).  
Tumor size reduction ranged from 15 to 67% in prostatic cancer, 12 to 25% in 
ovarian cancers, and no regrowth of surgically removed central nervous system 
tumors. Patients continued to take shark cartilage at a maintenance dose of 20 
grams per day, and as of June 1995, 34 months after the start of the trial, 14 
were alive and well.

Political difficulties between the U.S. and Cuba  prevented continued collaboration 
between myself and the Cuban researchers, interrupting plans to  present these 
results in peer review journals, but I believe that the investigation by CBS "60 
Minutes" was far more thorough than any peer review.  Mike Wallace and his 
team did not report what I said or wrote, they visited Cuba in person.  They 
interviewed the doctors and patients first-hand, and had the results, X-Rays, CAT 
scans, and biopsy slides, reviewed and confirmed by top oncologists in the U.S., 
including researchers at the National Cancer Institute who agreed that the 
remarkable results merited further study.

Details on these studies are available in my books, SHARKS DON'T GET CANCER, 
and SHARKS STILL DON'T GET CANCER available in most libraries and book 
stores, and via mail order (see the last page of this booklet for details).

6. Where does the research stand now?

Presently my efforts are being funded by Lane Labs-USA, and assisted by doctors 
and scientists around the world.  With their help, knowledge of how shark 
cartilage works and methods of processing natural shark cartilage into a stable and 
effective oral supplement have been refined.  Currently, an advanced form of 
shark cartilage, developed specifically for  medical and scientific research is 
undergoing  human clinical trials in several countries.  In the U.S., the F.D.A. has 
been sufficiently convinced of its potential to allow Phase II clinical trials (study 
approval was granted specifically on this form of shark cartilage identified by 
brand name, not on shark cartilage in general).

Animal studies and reports from doctors and their patients have confirmed the 
superior effectiveness of this clinical formulation of shark cartilage.  The results 
from studies in  Venezuela, and Japan have been particularly encouraging.  In 
Venezuela, a prominent surgical oncologist has documented hundreds of cases 
showing favorable outcomes in patients with cancerous and pre-cancerous 
conditions.  The Japanese research shows excellent responses on end-stage 
cancer patients, previously considered terminal.

7. For advanced cancers, what is the recommended dosage and dosage schedule, 
and for how long should it be taken?

In animal and human studies, the dosage used for advanced cancers is 1 gram per 
kilo of patient body weight per day of clinical quality shark cartilage (a kilo equals 
2.2 pounds).  However, because shark cartilage is believed to show a  dose 
response (higher doses have a greater or faster effect), and because high doses 
show no associated toxicity, many practitioners recommend higher doses on very 
advanced or rapidly developing cancers.  Dosages of up to 2 grams per kilo of 
body weight, per day have been shown to be well tolerated and effective.

Based on the 1 gram per kilo of body weight formula, here are sample daily 
dosage and schedule recommendations*:

Patient   Weight        Daily Shark             Before         Before       Before          Late 
Weight   in Kilos     Cartilage Dose         Breakfast       Lunch        Dinner       Evening

40 lbs    18.2         18 grams= 3 scoops      1 scoop       1 scoop      1 scoop           -
80 lbs     36.          36 grams= 6 scoops      2 scoops      2 scoops    2 scoops         -
120 lbs   54.5        54 grams= 9 scoops      3 scoops     3 scoops     3 scoops          -
160 lbs    72.7       72 grams=12 scoops     3 scoops     3 scoops     3 scoops     3 scoops
200 lbs    90.9       90 grams=15 scoops     4 scoops     4 scoops     4 scoops     3 scoops
220 lbs   100       100 grams=17 scoops      5 scoops     4 scoops    4 scoops    4 scoops

* Assumes use of clinical quality shark cartilage shark cartilage powder 
which comes with a 6 gram measuring scoop.  

Shark cartilage is thought to work through the effect of intestinally absorbed 
whole proteins, so if taken orally it should be taken on an empty stomach, 45 
minutes before eating to minimize the effects of stomach acid and digestion.  Daily 
dosages can be divided into two, three or four equal portions depending on patient 
preference.  Try to come up with a dosage regime that is easy to comply with 
every day (it is a big help if you can get a family member to prepare doses and 
keep track of your dosing schedule).  Many high dosage patients take up to 24 
grams at a time, mixed in water or juice, with a blender or just well shaken in a 
cup with a lid.  Clinical quality shark cartilage has a minimal taste and odor and 
can be easily taken by almost anyone.

Generally, patients stay on a high dose regime until the tumors are largely gone 
and blood markers are normal.  This is usually a minimum of 20 weeks, but will 
frequently take longer.  When the patient has shown significant improvement and 
is largely cancer free, the dosage can be lowered by 50% for 4 weeks, and then 
to a maintenance dose of 8 to 20 grams per day.

8. When I take shark cartilage, what effects should I look for, and how long before 
I notice any changes?

Every person and situation is unique, but based on the research and reports from 
doctors I can generalize about patients who use clinical quality shark cartilage at 
recommended dosages.  In almost every case by 4 to 6 weeks an improvement in 
well-being and quality of life is evident.  By the 8th to 10th week, significant pain 
reduction will occur, particularly in those with bone cancers.  The 12 to 14 week 
period is critical.  Changes may begin to occur within the tumor itself, reflected in 
tumor growth and blood markers.  Frequently, it is at this point that tumor growth 
and increases in blood markers slow or stop.  

Significant tumor reduction usually takes 20 weeks or longer.  Some patients will 
reduce their daily dose at this point (be cautious about reducing the dose too 
soon).  Because the experience of thousands of users has shown shark cartilage to 
be safe at high doses for long periods of time most practitioners recommend not 
cutting back on the daily dose until multiple and sequential tests show sustained 
improvement.  Many patients have told me they did not see tumor reduction for a 
year or more, but that disease stabilization, improvement in quality of life, and 
being able to return to a normal, active life-style was sufficient incentive to stay 
on the high dose regime for longer periods.

The tumor response to shark cartilage therapy may come more slowly than that 
which occurs from chemical or radiation treatment.  However, shark cartilage 
therapy doesn't trigger the severe adverse side effects associated with 
conventional therapies.  Although indications are that higher doses result in a 
faster response and therefore appropriate for very late advanced disease, it takes 
time for shark cartilage to have an effect.  Patients considering this therapy should 
have at least 8 to 10 weeks life expectancy.  Waiting until a patient only has a 
few days to live does not give it enough time to work.

9. If shark cartilage is effective on stage III and stage IV cancers, will it help in 
earlier stages?

I believe that shark cartilage can help at any stage of cancer, but I would never 
suggest that a patient abandon the currently accepted treatments.  Controlled 
clinical studies with shark cartilage have involved late-stage patients for whom no 
other therapy is thought to exist, however positive "anecdotal" reports from 
doctors and patients suggests that clinical quality shark cartilage may be 
appropriate in earlier stages.  There are many stages in the progression of cancers 
when there are no appropriate, "proven" therapies, and where using shark 
cartilage may be prudent:  -- When cancer has been detected, but when a specific 
diagnosis of cancer type or location is lacking. -- The "watchful waiting" periods 
between surgery and adjunctive therapies.  -- And of course, in the end stages 
when all surgical, radiation, chemotherapy and other options have been exhausted. 
 Consult with your oncologist and doctors who specialize in natural and nutritional 
therapies, and also seek out and learn from cancer survivors.  

10. Can shark cartilage be combined with other therapies?

As I always say, consult with your doctors.  Most cancer therapies involve 
multiple treatment modalities.  Chemotherapies, surgery and radiation are 
combined to the extent that their combined effect does not enhance the toxic or 
detrimental side-effects of each separately.  Shark cartilage itself has no known 
toxicity and has not been shown to reduce the effectiveness or increase the 
toxicity of other therapies.  In the rationale that directs the use of "poly-therapies", 
shark cartilage is harmless, and therefore, in most cases, allowable.

Shark cartilage may also be combined with most natural and nutritional therapies.  
Non-toxic therapies which aim to strengthen the body's own defenses, and focus 
on keeping the patient alive and healthy, rather than kill the cancer at any cost, 
share much philosophically with the shark cartilage approach.  Consult with a 
health care practitioner who specializes in natural and nutritional therapies for 
specific recommendations.

11. Is shark cartilage a cancer preventative?

My research has focused on late-stage cancers, but theoretically it should help. 
Many "anecdotal" reports from doctors and patients have shown improvement in 
precancerous conditions.  Shark cartilage (specifically Clinical quality shark 
cartilage) is certainly a safe and a healthful supplement, helpful in arthritis, 
psoriasis and number of conditions.  Many doctors who specialize in preventive 
medicine do recommend shark cartilage in combination with dietary guidelines, 
proper exercise and the use of specific vitamins and supplements.  My present 
belief, shared by many of the doctors I work with, is that a dosage of 7 to 10 
grams per day should prove to be a fairly good prophylactic dose for those who 
are at risk of cancer, or who have been treated and are presently cancer free.

12. Which is more effective, shark cartilage in the powder form or in caplets?

The only difference between the two is that caplets will contain inactive binding 
agents. Both should be equally effective, so the choice is up to patient preference, 
what ever is easiest to use on a regular and consistent basis. Many tell me they 
use the powder at home, and take caplets at work or when traveling.  Powdered 
shark cartilage is easier to take at high doses and is generally more economical.

13. Is shark cartilage more effective taken orally or via retention enema?

Because specific protein molecules have been identified as giving shark cartilage 
its antiangiogenic effect, and stomach acid may break these down into amino 
acids, I originally assumed that rectal administration, via retention enema, was the 
only way to go. Animal studies and human experience with oral administration, 
combined with a large body of research showing significant oral absorption of 
intact protein, has changed my mind on the subject.  I now believe that either 
method can be effective, so it is a matter of patient preference.  Patients who 
can't get use to the taste,  suffer from nausea, or are too weak to take shark 
cartilage orally, may find the retention enema route easier to comply with.  Quite a 
few patients mix the route of administration, taking their early morning, or late 
evening doses via enema, when it is convenient to lie in bed, and taking doses 
orally when they are up and around.

14. How do you take shark cartilage via retention enema?

The object of the retention enema, is to get the shark cartilage into the upper 
colon, where large molecule absorption takes place.  Unlike taking shark cartilage 
orally, you don't have to wait a set period before eating, but you should try having 
a bowel movement before taking shark cartilage rectally.  Mix the dosage of shark 
cartilage with less water than if you were to take it orally, approximately 1 ounce 
of water (bottled or distilled water are best)  to every 6 grams of shark cartilage 
powder and mix well.  A disposable "Fleet" enema bottle also works well as an 
applicator.  Fill with shark cartilage/water solution, insert tip into enema tip into 
rectum, and try to squeeze the shark cartilage solution as deeply as possible into 
the colon.  Lie down on back or side for 30 minutes.  The shark cartilage should 
not leak out and should be comfortably retained until your next bowel movement 
(overnight if you take a dose in the late evening).
 
15. Does it matter what shark cartilage product I use?

Getting good results with shark cartilage therapy depends on, A) appropriate 
dosage, B) consistent and persistent use, and most importantly, C) using a quality 
shark cartilage product.  I always emphasize the need to use a clinical quality 
shark cartilage, because after the "60 Minutes" broadcast on my clinical trial in 
Cuba, the market has been flooded by  untested "copy-cat" shark cartilage 
products.  Some are loaded with sugar, or diluted with other ingredients, including 
shark protein from non-cartilage sources to boost reported protein content.   In 
many cases the color (tan), rancid smell, or low cost is an immediate tip-off to 
poor quality (most of them have an awful smell and taste clearly demonstrating 
putrefaction).  I am particularly alarmed by the so-called liquid shark cartilage 
products.  They are over 99% water, and it is expected that less than a milligram 
of some "protein extract" can replace many grams of whole cartilage protein. 

A clinical quality shark cartilage is produced for use in animal and human studies, 
most shark cartilage supplements are produced merely for sale in a bottle.   The 
product I am using in my present research is produced in Australia and is the result 
of 15 years of research and through the collaboration of scientist throughout the 
world.  Results from comparative laboratory and animal research show that it is 
more effective than any other shark cartilage I have studied.  I believe this is due 
to the freshness and quality of the raw material used, the all-natural processing 
method, and the fact that the end product is highest in cartilage protein.  Although 
it is being tested in clinical trials as an investigational new drug, it is sold as a 
natural supplement in many pharmacies, health food stores, and by mail order.  
For information on where it can be obtained, call, 201-236-9090.  In a superficial 
comparison of color, smell, and taste, side by side with other shark cartilage 
products, this clinical quality shark cartilage is obviously superior.  

16. What is the difference between shark cartilage and bovine cartilage?

In my opinion the only similarity between is the common word "cartilage." Clinical 
quality shark cartilage acts to inhibit new blood vessel development through the 
effects of specific proteins, it also contains mucopolysacchrides and does 
stimulate the immune system. Bovine cartilage contains mucopolysacchrides which 
stimulate the immune system, but is devoid of the proteins needed to inhibit 
angiogenesis (some activity is shown in raw bovine cartilage but the processing 
with acetone needed to remove the large amounts of fat in bovine tracheal 
cartilage denatures all proteins and renders them inactive).  It does contain ample 
amounts of mucopolysaccharides which stimulate the immune system.

Since most cancer patients turn to cartilage and alternative therapies when they 
have failed conventional therapy and are usually in stage III or IV, I believe that 
stimulation of the immune system in this advanced stage is too little, too late.  
Here shark cartilage, with both immune stimulating and antiangiogenic effects,  
primarily the antiangiogenic effect is often highly effective.  The confusion 
regarding bovine versus shark cartilage result from the exaggerated claims made 
by bovine cartilage promoters based on the published results of a single 1985 case 
study. However, according to published results in true clinical trials (in peer review 
journals and in S.E.C. 10 K filings)  bovine cartilage has been effective in less than 
3% of 77 cases reported.  With early cancers both bovine and shark cartilage can 
be effective, in late stages, only shark has shown itself to be effective.

17. Does the production of shark cartilage supplements contribute to the over 
fishing of sharks?

Sharks are caught primarily for their fins, alone worth $100 to $300 per shark, 
and secondarily for their meat worth around $0.50 per pound.  Sharks are 
routinely fished for these products.  The raw shark cartilage is worth just $5 to $8 
per shark.  No fisherman would catch sharks just for the economic return from the 
cartilage, the monetary value for which is just an add-on from a carcass already on 
deck.  Thus I say the use of shark cartilage causes no pressure on the fishery as 
no sharks are caught specifically for cartilage.

Environmentalists opposed to shark fishing overlook two important points.  First of 
all most sharks are warm water fish, so Florida and California being 28 degrees 
North latitude are at the extreme of the shark belt and shark populations off North 
America are not indicative of global populations.  In Equatorial regions off the 
coasts of Central America, Africa, etc., there are ample sharks.  Secondly, marine 
biologists believe the greatest threat is the over development of coastal regions 
and the loss of wetlands and marshes which are necessary breeding grounds for 
both sharks and the fish they feed on.

18. Can the blood vessel inhibiting effect of shark cartilage treat other conditions?

Many diseases arise from or are supported by the abnormal formation of blood 
vessels which researchers classify as angiogenic dependent.  These include 
rheumatoid and osteo arthritis, psoriasis, scleroderma and non-cancerous tumors 
such as uterine fibroids, breast fibrosis, and hemangiomas (tumors which are a 
mass of capillaries).  In rheumatoid arthritis and to a lesser degree, osteo arthritis, 
 cartilage in joints is weakened by invaded blood capillaries. Excess vascularization 
of the eye is the most common cause of blindness and occurs with diabetic 
retinopathy, macular degeneration and neovascular glaucoma.  All angiogenic 
dependent conditions should respond to antiangiogenic treatment mechanisms.


Although I haven't been directly involved with clinical research on other 
conditions, many health care practitioners have reported positive results and 
suggested guidelines for the treatment of the following conditions:

                                           Therapeutic Level             Maintenance Level
                                              grams per day                  grams per day

Rheumatoid Arthritis              20 gms  for 4 weeks           4 gms on-going
Major relief should be noted    then 8 gms for 8 weeks

Psoriasis                               20 gms for 4 weeks               discontinue 
                                           12 gms for 4 weeks                with relief
Diabetic Retinopathy              20 gms for 4 weeks            6 gms on-going
                                                                                   or as a preventative

Osteo Arthritis                        6 gms for 3 weeks             2 gms on-going

Notes:  Chart assumes patient weight of 100 lbs, adjust dosage to actual 
weight. Assumes use of clinical quality cartilage, other shark cartilage brands 
typically require higher dosage levels.  For the treatment of serious disease it is 
always recommended that you consult with a qualified health care 
professional.

19. Can the blood vessel inhibiting effect of shark cartilage be dangerous?

I am not a medical doctor.  You should always consult with a doctor before 
starting any therapy to make sure it is appropriate and safe.  The antiangiogenic 
effect of shark cartilage is generally safe, because in adults the capillary network 
is stable and healthy new blood capillary development is rare.  Other than during 
pregnancy, wound healing, and in response to blockages in the blood stream, new 
blood vessel growth only occurs in connection with angiogenic dependent 
diseases. 

New blood vessel formation takes place in developing infants, so shark cartilage 
should not be taken by pregnant or nursing women.  Wound healing also requires 
new capillary growth, and so shark cartilage should be used cautiously 
immediately preceding deep surgery, and for a period of weeks after, until healing 
is substantially under way.  Ask your surgeon for guidance.  

Shark cartilage will not worsen high blood pressure, in fact the mineral content 
may be helpful, but if you have had a recent heart attack or have a history of 
coronary artery disease, consult with your cardiologist before taking shark 
cartilage.  The formation of collateral blood vessels around blockages is important 
for recovery from a heart attack.  In many cases you need to weigh the risks of 
cancer versus the risks of a heart condition.    

If you presently have excess blood calcium or diminished kidney function you 
should take into consideration the high calcium content of shark cartilage.  No 
problems associated with hypercalcemia have ever been reported to me, but it is a 
situation which should be discussed with a medical professional, and monitored if 
necessary.

20. What are the common problems associated with using shark cartilage orally?

Mild nausea and a bloating feeling sometimes occur.  In patients who have 
recently had chemo or radiation therapy, these feelings are more common and are 
problems no matter what they eat.  Ask a health care practitioner for strategies to 
restore healthy digestion.  

If nausea occurs during the first couple of days using shark cartilage, try taking an 
antacid, or an 1/8 teaspoon of baking soda in water, 5 minutes before taking your 
shark cartilage.  If it is still a problem, cut your daily dose back by a half or two 
thirds, to a level you can tolerate, and build back up to the full dose slowly over a 
week.  Many find it necessary to experiment mixing the powdered shark cartilage 
with different beverages until they find a more pleasant taste.   

21. How can I find a doctor who is knowledgeable about shark cartilage?

The success of shark cartilage therapy has many health care practitioners 
advocating its use.  My office maintains directory of health care professionals who 
are willing to advise patients on dosage and schedule of use.  Please call (860) 
628-6061 (in Connecticut), for the names of doctors near you, or for doctors who 
will consult by phone. 

22. Can I get my regular doctor to help me use shark cartilage?

The ultimate decision to use shark cartilage or any of the other therapy options, is 
the patient's, but monitoring by your oncologist or primary care doctor is helpful.  
Once they have reviewed the facts, most doctors will agree that shark cartilage is 
certainly safe and the research promising.  They can help you determine the 
proper dosage schedule and provide reports on your progress.  Please ask your 
doctor to call (860) 628-6061 and my office will send out details on the prior 
research and the treatment protocol being used in the F.D.A. allowed clinical trials. 
 

23. Can I talk to people who have used shark cartilage successfully?

I believe that the true "experts" on cancer are the cancer survivors themselves.  
My office maintains a network of people who have use shark cartilage successfully 
(for cancer, arthritis, and other conditions)  and want to help others by sharing 
their experiences.  They are inspiring to speak with, and what they have learned 
about conventional and alternative therapies is invaluable.  Call my office, (860) 
628-6061, and we will put you in touch with  survivors  with conditions, age or 
geographic locations similar to yours.

24. What other information is available?

My original book, SHARKS DON'T GET CANCER, and the updated, SHARKS STILL 
DON'T GET CANCER are the most complete sources of information on shark 
cartilage therapy.  The video tape documentary, "Shark Cartilage: A Promise 
Kept," is also educational, and because it contains the first hand accounts of 
cancer survivors, it is inspiring as well.  These are available in many book and 
health food stores, and can be ordered by phone (800) 742-7534 (find 
descriptions and pricing on the last page of this booklet).

My Internet website contains more information, and includes profiles of cancer 
survivors, a message forum, and a facility to E-mail my office . My website 
address is:   http:\\www.drlane.com/

A trained counselor is available to answer your specific questions in my 
Connecticut office (Monday - Thursday, 10 am to 4 pm EST),  please call (860) 
628-6061.

Please send your comments and questions to:

I. William Lane, Ph.D.
CARTILAGE CONSULTANTS, INC.
80 Woodland Road, Suite 4
Short Hills, NJ  07078

Phone: (860) 628-6061
Fax: (201) 467-2175

(c) Copyright 1997 Cartilage Consultants, Inc.

The approaches described by Dr. Lane in this brochure are not offered as cures, 
prescriptions, diagnoses, or a means of diagnosis to different conditions.  The 
information must be viewed as an objective compilation of existing data and 
research.  Dr. Lane assumes no responsibility in the correct or incorrect use of this 
information and no attempt should be made to use any of this information without 
the approval and guidance of your doctor.







Answer all your questions and learn  more about this breakthrough therapy through books and tapes by Dr. I. William Lane. 

SHARKS DON'T GET CANCER  by I. William Lane, Ph.D. and Linda Comac
   
 The ground breaking 1992 book that first brought shark cartilage therapy to the attention of the world: 
scientific theory, early research, first human trials.  Dr. Lane presents his pioneering work to develop a truly effective treatment for arthritis, psoriasis and tumor based cancers.

Book - 192 pages,  $11.95 plus $3.50 shipping

Audio Tape - 180 minutes $17.95 plus $3.50 shipping.

SHARKS STILL DON'T GET CANCER by I. W. Lane, Ph.D. and Linda Comac
  
 Published in 1996 this new book  includes updates on the latest discoveries and answers the critical questions doctors and patients need to know about the treatment of cancer, arthritis, psoriasis, diabetic retinopathy and other chronic conditions.  Dr. Lane provides photographic evidence on the effects in tumor tissues by the administration of shark cartilage, results of the "Cuban" clinical trials at 40 months, details on new clinical trials and profiles of  patients, doctors and scientists.

Book - 246 pages,  $12.95 plus $3.50 shipping

Audio Tape - 180 minutes $17.95 plus $3.50 shipping.

SHARK CARTILAGE: A PROMISE KEPT  Narrated by Dr. Lane.
    
This video documentary explains shark cartilage therapy through interviews with patients who are using shark cartilage and doctors from around the world who have come to trust the effectiveness of this all natural therapy.  Watch it to learn how shark cartilage works, what conditions it can help, what dosages to take - even how to tell  the difference between clinical quality shark cartilage and the copy-cats.  

VHS Video Tape, 20 minutes $19.95 plus $3.50 shipping
      
Special Offer: FREE shipping when you order a video with any book or tape!

Available in many libraries and book stores by directly from Cartilage Consultants Book Department.   Mastercard, Visa, and Discover accepted.  Order by phone  800-742-7534, or make
checks payable to Cartilage Consultants and mail to:
    
Cartilage Consultants- Book Dept. P.O. Box 434  Short Hills, NJ 07078