FW: TGF-beta vaccine: where is it? [00345] Medicine On Line


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FW: TGF-beta vaccine: where is it?




Recent research I've read about appears to suggest an interesting venue for 
handling aggressive tumor cells, such aa adenocarcinomas. It is a new 
vaccine from genetically engineered cells, reserached mostly, I belive, at 
UCLA. The vaccine would prevent malignant cells from producing TGF-beta, and 
would therefore presumably allow the immune system to function. My 
understanding is that TGF-beta cloaks the  cancer cells, thus supressing the 
immune system and protecting the cancer. With the vaccine, the immune system 
would function in an  unimpeded manner. Do anyone know where there are 
clinical trials on this agent,and who would be the contact person. Your help 
would be much appreciated.

Thank you,

Howard Katz                 HKATZ@IS.MGH.MCGILL.CA